摘要
骨髓增殖性肿瘤(MPN)是一组造血干细胞克隆性疾病,JAK2V 617F基因突变为MPN诊断的主要依据。既往研究显示MPN患者BCR-ABL融合基因与JAK2 V617F基因突变是互相排斥的,但近年来两种基因双突变病例时有报道。文章综合近年来国内外相关文献,对BCR-ABL融合基因与JAK2 V617F突变双阳性的MPN进行综述。
Myeloproliferative neoplasms (MPN) are a group of clonal disorders of hematopoietic stem cells, and JAK2 V617F gene mutation is the main basis for the diagnosis of MPN. Previous studies have shown that BCR-ABL fusion gene and JAK2 V617F gene mutation are mutually exclusive in MPN patients, but in recent years, patients with a double mutation of both genes are often reported. The article synthesizes the relevant domestic and foreign literature in recent years, and reviews the BCR-ABL fusion gene and JAK2 V617F mutation double-positive MPN.
作者
邢明泉
葛洪峰
吴维霞
孙晓星
马兰
王其凯
韩浩
Xing Mingquan;Ge Hongfeng;Wu Weixia;Sun Xiaoxing;Ma Lan;Wang Qikai;Han Hao(Department of Hematology,Bozhou People's Hospital,Bozhou 236800,China;Image Center,Bozhou People's Hospital,Bozhou 236800,China;Department of Infectious Medicine,Bozhou People's Hospital,Bozhou 236800,China)
出处
《白血病．淋巴瘤》
CAS
2022年第10期637-640,共4页
Journal of Leukemia & Lymphoma
