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A cis-eQTL in NSUN2 promotes esophageal squamous-cell carcinoma progression and radiochemotherapy resistance by mRNA-m^(5)C methylation

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摘要 Dear Editor,Esophageal squamous cell carcinoma(ESCC)has poor prognosis because of the difficulty in early detection and low sensitivity of advanced disease to radiochemotherapy.1,2 ESCC presents a high proportion of primary resistance to radiochemotherapy,2which may be due to certain individual genetic variations.Expression quantitative trait loci(eQTLs)as proximal and continuous cellular phenotypes have been shown to be helpful to determine how genetic variants may influence phenotype.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2022年第9期3190-3193,共4页 信号转导与靶向治疗(英文)
基金 This study was funded by National Science Fund for Distinguished Young Scholars(81725015 to CW) Chinese Academy Medical Sciences Innovation Fund for Medical Sciences(2021-2M-1-013) Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023027 to C.W.) National Natural Science Foundation of China(81988101 to D.L.and C.W.).
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