摘要
目的探讨2型糖尿病伴有桥本甲状腺炎患者经左甲状腺素钠片+胰岛素+口服降糖药完成联合治疗后获得临床效果。方法选取2019年1月—2022年1月甘肃省甘南藏族自治州人民医院收治的2型糖尿病伴有桥本甲状腺炎的100例患者为研究对象;依据治疗方法的不同分为两组,各50例。参照组实施左甲状腺素钠片+胰岛素治疗,研究组实施左甲状腺素钠片+胰岛素+口服降糖药治疗;比较两组患者的药物治疗效果、空腹血糖水平、糖化血红蛋白水平、餐后2 h血糖水平、血糖曲线下面积数、修整胰岛β细胞分泌指数以及不良反应情况。结果研究组治疗总有效率(96.00%)高于参照组的76.00%,差异有统计学意义(P<0.05)。治疗前,两组空腹血糖水平、糖化血红蛋白水平、餐后2 h血糖水平、血糖曲线下面积数以及修整胰岛β细胞分泌指数比较,差异无统计学意义(P>0.05);治疗后,研究组空腹血糖水平、糖化血红蛋白水平、餐后2 h血糖水平、血糖曲线下面积数较参照组更低,差异有统计学意义(P<0.05);研究组修整胰岛β细胞分泌指数较参照组更高,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论左甲状腺素钠片+胰岛素+口服降糖药治疗较左甲状腺素钠片+胰岛素治疗效果更确切,并且安全性较高,可将2型糖尿病伴有桥本甲状腺炎患者胰岛功能水平、血糖水平更好改善。
Objective To explore the clinical effects obtained after the completion of combined treatment with levothyroxine sodium tablets+insulin+oral hypoglycemic agents in patients with type 2 diabetes mellitus with Hashimoto’s thyroiditis.Methods One hundred patients with type 2 diabetes mellitus with Hashimoto’s thyroiditis admitted to Gannan Tibetan Autonomous Prefecture People’s Hospital in Gansu Province from January 2019 to January 2022 were selected for the study.According to the different treatment methods,they were divided into two groups of 50 cases each.The reference group was treated with levothyroxine sodium tablets+insulin,and the study group was treated with levothyroxine sodium tablets+insulin+oral hypoglycemic agents.The drug treatment effect,fasting blood glucose level,glycosylated hemoglobin level,2 h postprandial blood glucose level,area under the blood glucose curve,modified isletβ-cell secretion index and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the study group(96.00%)was higher than that in the reference group(76.00%),and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in fasting blood glucose level,glycosylated hemoglobin level,2 h postprandial blood glucose level,number of area under the blood glucose curve and modified isletβ-cell secretion index between the two groups(P>0.05).After treatment,the fasting blood glucose level,glycosylated hemoglobin level,2 h postprandial blood glucose level and area under the blood glucose curve were lower in the study group compared with the reference group,and the difference was statistically significant(P<0.05).The study group had a higher index of modified isletβ-cell secretion than the reference group,and the difference was statistically significant(P<0.05).The difference was not statistically significant when comparing the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Levothyroxine sodium tablets+insulin+oral hypoglycemic therapy has more definite effect than levothyroxine sodium tablets+insulin therapy and is safer,which can improve the level of islet function and blood glucose level better in patients with type 2 diabetes mellitus with Hashimoto’s thyroiditis.
作者
李海燕
李进祥
李瑞莲
LI Haiyan;LI Jinxiang;LI Ruilian(Department of General Internal Medicine,Gansu Gannan Tibetan Autonomous Prefecture People's Hospital,Gannan Tibetan Autonomous Prefecture,Gansu Province,747000 China)
出处
《糖尿病新世界》
2022年第20期69-72,共4页
Diabetes New World Magazine
关键词
左甲状腺素钠片
胰岛素
降糖药
2型糖尿病
桥本甲状腺炎
疗效
血糖指标
Levothyroxine sodium tablets
Insulin
Glucose-lowering drugs
Type 2 diabetes mellitus
Hashimoto’s thyroiditis
Efficacy
Glycemic index
