摘要
目的探究沙库巴曲缬沙坦、缬沙坦2种药物分别在对慢性心力衰竭患者治疗过程中的近期效果差异。方法选择睢县中医院2019年5月至2020年12月住院治疗的慢性心力衰竭患者64例。依靠随机数字表法,将全部患者分为对照组(32例)、观察组(32例)。对照组在常规治疗基础上给予口服缬沙坦。观察组在常规治疗基础上给予口服沙库巴曲缬沙坦。两组患者的治疗时间长度均设定为1个月。对比两组的疗效,治疗前及治疗之后的心脏彩超指标、心功能指标(6 min步行试验),对比两组的用药不良反应。结果观察组的治疗效果分级优于对照组,差异有统计学意义(P<0.05)。经过治疗后,两组患者的舒张早期最大充盈速度、左心室射血分数、6 min步行距离均增加,舒张晚期最大充盈速度均降低,同治疗前相比,差异均有统计学意义(P<0.05)。治疗后,观察组的舒张早期最大充盈速度、左心室射血分数、6 min步行距离高于对照组,观察组的舒张晚期最大充盈速度低于对照组,差异均有统计学意义(P<0.05)。两组在治疗过程中均未发生严重不良反应。结论在慢性心力衰竭患者的救治过程中,采用沙库巴曲缬沙坦相对于传统的缬沙坦,可以获得更好的治疗效果,在短时间内更有利于改善患者的心功能,同时具有良好的安全性,但该药物的远期效果尚需探讨。
Objective To explore the differences in the short-term effects of Sakubactril valsartan and valsartan in the treatment of patients with chronic heart failure.Methods 64 patients with chronic heart failure who were hospitalized at Suixian Hospital of Traditional Chinese Medicine from May 2019 to December 2020 were selected.All patients were divided into a control group(32 cases)and an observation group(32 cases)by random number table method.The control group was given oral valsartan on the basis of conventional treatment.The observation group was given sakubactril valsartan orally on the basis of conventional treatment.The length of treatment for both groups was set to 1 month.The efficacy of the two groups was compared,as well as the indexes of cardiac color ultrasound and cardiac function before and after treatment(6 min walking test),and the adverse drug reactions between the two groups were compared.Results The treatment effect of the observation group was better than the control group,the difference was statistically significant(P<O.05).After treatment,the maximum filling velocity,left ventricular ejection fraction and 6 min walking distance in the early diastolic period were increased,while the maximum filling velocity in the late diastolic period was decreased in both groups,with statistical significance compared with before treatment(P<0.05).After treatment,the maximum filling velocity,left ventricular ejection fraction and 6 min walking distance in the early diastolic period in the observation group were higher than those in the control group,while the maximum filling velocity in the late diastolic period in the observation group was lower than that in the control group,with statistical significance(P<0.05).No serious adverse reactions occurred in the two groups during the treatment.Conclusion In the treatment process of patients with chronic heart failure,compared with traditional valsartan,the use of Shakubactril valsartan can achieve a better therapeutic effect,is more conducive to improving patients cardiac function in a short time and has good safety,but the long-term effect of this drug still needs to be discussed.
作者
周浩
ZHOU Hao(Department of Cardiology,Suixian Hospital of Traditional Chinese Medicine,Shangqiu Henan 476900,China)
出处
《临床研究》
2023年第1期45-47,共3页
Clinical Research
