摘要
目的分析生长抑制因子4、蛋白激酶D1与早期子宫内膜癌的关系及对淋巴结转移的预测效能。方法选取2018年1月至2021年10月南京市妇幼保健院接诊的256例接受子宫切除及淋巴结清扫术治疗的早期子宫内膜癌患者作为观察组,另选取同期诊治的256例子宫内膜增生症患者作为对照组。比较两组血清生长抑制因子4、蛋白激酶D1水平,绘制受试者工作特征(ROC)曲线评价血清生长抑制因子4、蛋白激酶D1对淋巴结转移的预测效能。结果观察组血清生长抑制因子4水平低于对照组,蛋白激酶D1水平均高于对照组,差异具有统计学意义(P<0.05)。观察组术后血清生长抑制因子4较术前升高,蛋白激酶D1水平均较术前降低,差异具有统计学意义(P<0.05)。血清生长抑制因子4联合蛋白激酶D1诊断早期子宫内膜癌的灵敏度为87.50%,特异度为86.33%。在256例早期子宫内膜癌患者中,发生淋巴结转移32例;淋巴结转移组术前血清生长抑制因子4低于非淋巴结转移组,蛋白激酶D1水平高于非淋巴结转移组,差异具有统计学意义(P<0.05)。经ROC曲线分析,血清生长抑制因子4联合蛋白激酶D1预测早期子宫内膜癌患者发生淋巴结转移的曲线下面积(AUC)为0.924。结论血清生长抑制因子4、蛋白激酶D1均与早期子宫内膜癌的病情演变有关,两者联合预测淋巴结转移的效能较好,值得进一步研究应用。
Objective To analyze the relationship between growth inhibitory factor 4 and protein kinase D1 and early endometrial carcinoma and the prediction of lymph node metastasis.Methods 256 cases of early endometrial cancer treated by hysterectomy and lymph node dissection in Nanjing Maternal and Child Health Hospital from January 2018 to October 2021 were selected as the observation group,and 256 cases of endometrial hyperplasia treated during the same period were selected as the control group.The levels of serum growth inhibitory factor 4 and protein kinase D1 were compared between the two groups.The predictive efficacy of serum growth inhibitory factor 4 and protein kinase D1 on lymph node metastasis was evaluated by area under receiver operating characteristic(ROC)curve.Results The serum growth inhibitor 4 level in the observation group was lower than that in the control group,and the protein kinase D1 level was higher than that in the control group,and the differences were statistically significant(P<0.05).In the observation group,the serum growth inhibitor 4 level was increased and the protein kinase D1 level was decreased after operation compared with that before operation,and the differences were statistically significant(P<0.05).The sensitivity and specificity of serum growth inhibitory factor 4 combined with protein kinase D1 in the diagnosis of early endometrial carcinoma were 87.50%and 86.33%.Lymph node metastasis occurred in 32 of 256 patients with early endometrial carcinoma.Preoperative serum growth inhibitory factor 4 and protein kinase D1 levels in lymph node metastasis group are lower than those in non-lymph node metastasis group,and the differences are statistically significant(P<0.05).ROC curve analysis showed that area under curve(AUC)of serum growth inhibitory factor 4 combined with protein kinase D1 in predicting lymph node metastasis in patients with early endometrial cancer is 0.924.Conclusions Serum growth inhibitory factor 4 and protein kinase D1 are associated with the disease evolution of early endometrial carcinoma,and their combined efficacy in predicting lymph node metastasis is good,which is worthy of further study and application.
作者
唐卉
张蕾
岳嫒媛
支小改
TANG Hui;ZHANG Lei;YUE Aiyuan;ZHI Xiaogai(Department of Gynecology,Nanjing Maternal and Child Health Hospital,Nanjing 210004,Jiangsu,China)
出处
《中国性科学》
2022年第12期125-129,共5页
Chinese Journal of Human Sexuality
关键词
子宫内膜癌
生长抑制因子4
蛋白激酶D1
淋巴结转移
预测
Endometrial carcinoma
Growth inhibitory factor 4
Protein kinase D1
Lymph node metastasis
Prediction
