摘要
正常生理状态下,机体内存在种类复杂、多样的微生物群体,构成动态平衡的微生态系统。女性生殖系统向外通过阴道口与外界相通,生殖道内定植微生物参与调节生殖道稳态、代谢、炎症及免疫防御等生理病理过程,其微生物群组成(种类或数量)异常,可能与女性不孕不育相关疾病密切相关。笔者拟就女性不孕不育相关疾病患者,如多囊卵巢综合征(PCOS)、早发性卵巢功能不全(POI)、慢性子宫内膜炎(CE)、子宫内膜异位症(EMS)及子宫腺肌病等患者的生殖道微生物组成异常的最新研究进展进行阐述,旨在为临床对这些疾病的发病机制和诊治提供新思路。
Under normal physiological conditions,there are complex and diverse types of microorganisms in the body,forming a dynamic and balanced micro-ecosystem.Female reproductive system communicates with the outside world through vaginal orifice.Colonized microorganisms in reproductive tract participate in regulating the physiological and pathological processes of homeostasis,metabolism,inflammation and immune defense in reproductive tract,whose abnormal microbiota composition(type or quantity)may closely related to female infertility-related diseases.The author intends to elaborate on the latest research progress in reproductive tract microorganism abnormalities in female infertility-related diseases,such as polycystic ovary syndrome(PCOS),premature ovarian insufficiency(POI),chronic endometritis(CE),endometriosis(EMS)and adenomyosis,aiming to provide new ideas for the clinical mechanism,diagnosis and treatment of female infertility-related diseases.
作者
陈雨婷
杨烨
谢奇君
凌秀凤
Chen Yuting;Yang Ye;Xie Qijun;Ling Xiufeng(Reproductive Medicine Center,Women′s Hospital of Nanjing Medical University,Nanjing 210004,Jiangsu Province,China)
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2022年第5期615-620,共6页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
国家自然科学基金项目(81871210)。
