摘要
目的:研究生长因子辅助内括约肌保留下行挂线疗法对肛周脓肿患者的影响。方法:选取2017年11月-2020年11月在宁德师范学院附属宁德市医院接受治疗的肛周脓肿患者168例作为研究对象,以随机法分为挂线疗法组和因子联合组,各84例,挂线疗法组使用内括约肌保留下行挂线疗法治疗,因子联合组使用生长因子辅助内括约肌保留下行挂线疗法治疗。治疗前及术后14 d,统计肛门功能,以及采用酶联免疫吸附法检测白介素-2(IL-2)、白介素-12(IL-12)、血管内皮生长因子(VEGF)、血小板衍生生长因子(PDGF);术后14 d评价临床疗效及不良事件,并针对两组创面愈合率进行对比。结果:术后14 d,与挂线疗法组相比,因子联合组肛门功能更优,差异有统计学意义(P<0.05);因子联合组IL-2、IL-12水平均显著更低,差异均有统计学意义(P<0.05);与挂线疗法组相比,因子联合组VEGF、PDGF水平均显著更高,差异均有统计学意义(P<0.05);与挂线疗法组相比,因子联合组治疗总有效率较高,差异有统计学意义(P<0.05);与挂线疗法组相比,因子联合组不良事件发生率较低,但差异无统计学意义(P>0.05)。与挂线疗法组相比,因子联合组创面愈合率较高,差异有统计学意义(P<0.05)。结论:生长因子辅助内括约肌保留下行挂线疗法可以降低肛周脓肿患者不良事件,创面愈合效果显著。
Objective:To study the effect of growth factor assisted internal sphincter retained hang line therapy on perianal abscess patients.Method:A total of 168 patients with perianal abscess treated in Ningde Municipal Hospital of Ningde Normal University from November 2017 to November 2020 were selected as the research objects.They were randomly divided into hang line therapy group(n=84)and factor combination group(n=84).The hang line therapy group was treated with the internal sphincter hang line therapy,and the factor combination group was treated with the growth factor-assisted internal sphincter hang line therapy.Before treatment and 14 d after operation,partial anal incontinence,perianal eczema and humidity were counted,and interleukin-2(IL-2),interleukin-12(IL-12),vascular endothelial growth factor(VEGF)and platelet-derived growth factor(PDGF)were detected by enzyme-linked immunosorbent assay.The clinical efficacy and adverse events were evaluated 14 days after operation,and the wound healing rate of the two groups was compared.Result:At 14 d after surgery,compared to the hang line therapy group,the anal function in factor combination group was better,the difference was significant(P<0.05);the IL-2,IL-12 levels in factor combination group were significantly lower,the differences were all significant(P<0.05).Compared to the hang line therapy group,the levels of VEGF and PDGF were significantly higher in the factor combination group,the differences were all significant(P<0.05).Compared to the hang line therapy group,the overall response rate was higher in the factor combination group,the difference was statistically significant(P<0.05).Compared to the hang line therapy group,incidence of adverse events in the factor combination group was lower,however,the difference was not significant(P>0.05).The wound healing rate in the factor combination group was higher compared with that in the factor combination group(P<0.05).Conclusion:The growth factor assisted internal sphincter retained hang line therapy can reduce the adverse events in patients with perianal abscess,and the wound healing effect is significant.
作者
夏悦明
陈招武
吴淑桃
XIA Yueming;CHEN Zhaowu;WU Shutao(Ningde Municipal Hospital of Ningde Normal University,Ningde 352100,China)
出处
《中国医学创新》
CAS
2022年第27期116-120,共5页
Medical Innovation of China
关键词
生长因子
内括约肌保留下行挂线疗法
肛周脓肿
创面愈合
肛门功能
Growth factor
Internal sphincter retained hang line therapy
Perianal abscess
Wound healing
Anal function
