摘要
目的观察加味补中益气汤联合戊酸雌二醇/雌二醇环丙孕酮片治疗女性肾阴虚肝郁型更年期综合征的临床疗效及对病人血清促卵泡激素(FSH)、黄体生成激素(LH)表达的影响。方法按随机数字表法将2019年4月至2021年1月唐山市人民医院收治的198例女性肾阴虚肝郁型更年期综合征病人分入观察组与对照组(各99例)。对照组给予戊酸雌二醇/雌二醇环丙孕酮片治疗,观察组在对照组治疗基础上联合加味补中益气汤治疗。比较两组病人临床疗效、中医证候评分,应用女性绝经期自测表(Kupperman改良评分)评估病人治疗前后临床症状改善情况,检测血清FSH、LH水平及不良反应情况。结果治疗后,与对照组(70.70%)相比,观察组总有效率(90.90%)更高(P<0.05)。治疗后两组月经紊乱、潮热汗出、急躁易怒、阴道干涩、腰膝酸软、舌质暗红苔薄等各项中医证候评分均降低,且观察组低于对照组(P<0.05)。治疗后两组Kupperman积分均降低,且观察组低于对照组(P<0.05);治疗后两组血清FSH、LH水平降低,雌二醇(E_(2))水平升高,且观察组血清FSH、LH水平低于对照组,E_(2)水平高于对照组(P<0.05);与对照组(13.13%)相比,观察组不良反应发生率(4.04%)更低(P<0.05)。结论加味补中益气汤联合戊酸雌二醇/雌二醇环丙孕酮片治疗女性肾阴虚肝郁型更年期综合征疗效显著,可降低中医证候评分,缓解病人病情严重程度,降低血清FSH、LH水平,升高E_(2)水平,改善生殖内分泌系统功能,且不良反应少,安全可靠。
Objective To investigate the clinical efficacy of Jiawei Buzhong Yiqi decoction combined with kelingmeng in the treat-ment of female menopausal syndrome with kidney yin deficiency and liver depression and its effect on serum follicle-stimulating hor-mone(FSH)and luteinizing hormone(LH).Methods A total of 198 female patients with menopausal syndrome of kidney yin deficien-cy and liver depression in Tangshan People's Hospital from April 2019 to January 2021 were assigned into treatment group and control group(99 cases in each group)by random number table method.The control group was given klingmeng treatment,while the observa-tion group was treated with modified Buzhong Yiqi decoction on the basis of the treatment of the control group.The clinical efficacy and TCM syndrome scores were compared in two groups,and the women's menopausal self-test(kupperman's modified score)was used to evaluate the improvement of clinical symptoms before and after treatment,and serum FSH and LH levels and adverse reactions were an-alyzed.Results After treatment,compared with the control group(70.70%),the observation group had a higher total effective rate(90.90%)(P<0.05).After treatment,the scores of menstrual disorders,hot flashes,sweating,irritability,vaginal dryness,sore waist and knees,dark red tongue and thin coating were all reduced in the two groups,and compared with the control group,the scores in the observation group was lower(P<0.05).After treatment,the kupperman scores of the two groups decreased,and compared with the control group,the kupperman score in observation group was lower(P<0.05).After treatment,the serum FSH and LH levels of the two groups decreased,and the estradiol(E_(2))level increased,and compared with the control group,the serum FSH and LH levels in observation group were lower,E_(2)level was higher(P<0.05).Compared with the control group(13.13%),the incidence of adverse reactions in the observation group(4.04%)was lower(P<0.05).Conclusion Jiawei Buzhong Yiqi decoction combined with kelingmeng has a significant effect on the treatment of female menopausal syndrome with kidney yin deficiency and liver depression,which can reduce the TCM syndrome score,relieve the severity of condition,reduce serum FSH and LH levels,increase E_(2) levels,and improve the reproductive endocrine system functions with few adverse reactions,and is safe and reliable.
作者
王燕
郗轶楠
张娜
孙星
翟琪
WANG Yan;XI Yinan;ZHANG Na;SUN Xing;ZHAI Qi(Department of Obstetrics and Gynecology,Tangshan People's Hospital,Tangshan,Hebei 063000,China)
出处
《安徽医药》
CAS
2022年第11期2313-2317,共5页
Anhui Medical and Pharmaceutical Journal
基金
河北省卫生厅基金科研项目(20181222)
河北省中医药管理局科研计划项目(2018339)。
