摘要
目的探讨加味通络方治疗气虚血瘀兼阴虚型急性脑梗死患者的效果及对患者巯基丙酮酸硫基转移酶-3(3-MST)、血管内皮生长因子(VEGF)、血管紧张素Ⅱ(AngⅡ)水平、美国国立卫生研究院卒中量表(NIHSS)、经颅多普勒超声(TCD)指标的影响。方法选取2021年1月至12月牡丹江医学院附属红旗医院收治的100例气虚血瘀兼阴虚型急性脑梗死患者作为研究对象,采用随机数字表法将其分为观察组和对照组,每组各50例。观察组患者采用加味通络方治疗,对照组患者采用常规西医治疗。比较两组患者治疗前后的NIHSS评分、3-MST、AngⅡ、VEGF水平;比较两组患者治疗前后的各项TCD指标水平。结果治疗前,两组患者的血清3-MST水平比较,差异无统计学意义(P>0.05);观察组患者治疗后的血清3-MST水平高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的血清VEGF、AngⅡ水平比较,差异无统计学意义(P>0.05);观察组患者治疗后的血清VEGF水平高于对照组,AngⅡ水平低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的NIHSS评分比较,差异无统计学意义(P>0.05);观察组患者治疗后的NIHSS评分低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的血流频谱形态(Vs)、平均血流速度(Vm)、搏动指数(PI)水平比较,差异无统计学意义(P>0.05);观察组患者治疗后的Vs、Vm水平低于对照组,PI高于对照组,差异有统计学意义(P<0.05)。结论加味通络方对气虚血瘀兼阴虚型急性脑梗死治疗效果明显,可有效调控建立脑侧支代偿血管,进一步达到控制血清各项水平的目的。
Objective To investigate the effect of Jiawei Tongluo Recipe on patients with acute cerebral infarction of Qi deficiency and blood stasis combined with Yin deficiency,and the effect of Jiawei Tongluo Recipe on patients with mercaptopyruvate thiotransferase-3(3-MST),vascular endothelial growth factor(VEGF),angiotensinⅡ(AngⅡ),National Institutes of Health Stroke scale(NIHSS)and transcranial Doppler(TCD)indicators.Methods A total of 100 patients with acute cerebral infarction of Qi deficiency and blood stasis combined with Yin deficiency admitted to Hongqi Hospital Affiliated to Mudanjiang Medical University from January to December 2021 were selected as the research objects.They were divided into observation group and control group by random number table method,with 50 cases in each group.The patients in the observation group were treated with Jiawei Tongluo Recipe,while the patients in the control group were treated with conventional Western medicine.The NIHSS scores,the levels of 3-MST,AngⅡand VEGF before and after treatment were compared between the two groups.The levels of TCD indexes before and after treatment were compared between the two groups.Results Before treatment,there were no significant differences in serum 3-MST levels between the two groups(P>0.05).The serum 3-MST level of the observation group after treatment was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no significant differences in serum VEGF and AngⅡlevel between the two groups before treatment(P>0.05).The serum VEGF level of the observation group after treatment was higher than that of the control group,the AngⅡlevel of the observation group after treatment was lower than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in NIHSS score between the two groups before treatment(P>0.05).The NIHSS score of the observation group after treatment was lower than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in blood flow spectrum morphology(Vs),mean blood flow velocity(Vm)and pulsitility index(PI)between the two groups(P>0.05).After treatment,the Vs and Vm levels of the observation group were lower than those of the control group,and PI of the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Jiawei Tongluo Recipe has obvious effect on on patients with acute cerebral infarction of Qi deficiency and blood stasis combined with Yin deficiency.It can effectively regulate and establish cerebral collateral compensatory vessels and further control various serum levels.
作者
栗昭生
那丽莎
贾茜
曲娜
关亚新
LI Zhaosheng;NA Lisha;JIA Qian;QU Na;GUAN Yaxin(Department of Neurology,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Province,Mudanjiang157011,China;Department of Pharmacy,Hongqi Hospital Affiliated to Mudanjiang Medical College,Heilongjiang Province,Mudanjiang157011,China)
出处
《中国当代医药》
CAS
2022年第28期107-110,共4页
China Modern Medicine
基金
黑龙江省中医药科研项目(ZHY2020-181)。
关键词
加味通络方
气虚血瘀
阴虚型
急性脑梗死
效果分析
Jiwei Tongluo Recipe
Qi deficiency and blood stasis
Yin deficiency type
Acute cerebral infarction
Effect analysis
