摘要
目的分析目前华西肠癌数据库(Database from Colorectal Cancer,DACCA)中,华西医院作为区域性中心所服务的结直肠患者的ABO血型对手术特征及术后并发症的影响。方法本次数据分析选取的DACCA版本为2022年1月5日更新版,其中分析的数据项目包括:ABO血型、性别、手术类型、手术性质及术后并发症。对不同血型(A型、B型、AB型、O型)结直肠癌患者的手术特征及术后在院期间、术后近期和术后远期3个不同时期的并发症发生情况进行分析。结果按照条件筛选DACCA数据库,获得5010条可分析数据行,数据涵盖2005–2022年。血型特征性分析结果显示:术后总体并发症及其术后在院期间、术后近期和术后远期阶段并发症发生情况在不同血型间的差异均无统计学意义(P>0.05);进一步亚组分析,仅术后在院期间的吻合口漏在不同血型间的差异有统计学意义(χ^(2)=9.588,P=0.022)。结肠癌手术的原发灶切除与否和原发灶根治度以及直肠癌手术的保肛与否在不同血型间的差异均无统计学意义(P>0.05),直肠癌原发灶不同根治度在不同血型间的差异有统计学意义(χ^(2)=15.773,P=0.001)。结论结直肠癌患者的ABO血型与术后近期和术后远期的总体并发症的发生无关,也对不同的手术方式的实施不造成影响,但单一的术后吻合口漏的发生与血型相关,其可能原因尚需进一步探讨。
Objective To analyze the influence of the ABO blood types of colorectal cancer patients served by West China Hospital as a regional center on surgical characteristics and postoperative complications in the current version of Database from Colorectal Cancer(DACCA).Methods The DACCA version was updated on January 5,2022.The data items included ABO blood type,sex,type of operation,nature of operation and postoperative complications.The operative characteristics and complications at different stages after operation(in hospital,short-term and long-term after operation)of colorectal cancer patients with different blood types(A,B,AB,O)were analyzed.Results According to the DACCA database,we obtained 5010 analysable data rows,covering 2005–2022.The results of blood types analysis showed that there was no significant difference among different blood types in the overall postoperative complications and the occurrence of complications in hospital,short-term and long-term after operation(P>0.05).Further subgroup analysis showed that only the difference of anastomotic leakage among different blood types was statistically significant(χ^(2)=9.588,P=0.022).There was no significant difference among different blood types in whether the primary focus of colon cancer surgery was removed or not,the degree of radical resection of the primary focus,and whether the anus was preserved or not in rectal cancer surgery(P>0.05),and there was significant difference among different blood types with different degrees of radical resection of primary rectal cancer(χ^(2)=15.773,P=0.001).Conclusions The ABO blood types of patients with colorectal cancer has nothing to do with the occurrence of overall complications in the short and long term after operation,and has no impact on the implementation of different surgical methods.However,the occurrence of a single postoperative anastomotic leakage is related to blood type,and its possible causes need to be further explored.
作者
韦宇豪
谢欣雨
赵天浪
汪晓东
李立
WEI Yuhao;XIE Xinyu;ZHAO Tianlang;WANG Xiaodong;LI Li(Departnent of Gastrointestinal Surgery,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;West China School of Medicine in Sichuan University,Chengdu 610041,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2022年第9期1226-1230,共5页
Chinese Journal of Bases and Clinics In General Surgery
基金
四川大学大学生创新创业项目(项目编号:C2022119081)。
关键词
ABO血型
结直肠癌
术后并发症
手术类型
手术性质
ABO blood type
colorectal cancer
postoperative complications
surgical type
nature of surgery
