摘要
微针是一种新型的药物经皮递送技术,能穿透皮肤角质层,形成微孔通道,促进药物的渗透和吸收,在药物递送中有重要作用.本文从微针的结构和功能特点,系统阐述了聚合物微针的结构和功能设计,以及制造聚合物微针的材料和方法、微针的给药方式;综述了微针经皮递送技术近年来在抗肿瘤、疫苗递送、血糖调控、组织液提取和检测,以及生物传感等领域中的研究进展,并对其优势及存在的问题进行分析,总结了微针技术发展需要解决的关键问题,展望了微针疫苗未来的发展方向.
Microneedle(MNs)is a new technology for transdermal drug delivery,which can penetrate the stratum corneum to form micropore channels and promote the penetration and absorption of drugs.Based on the structure and function properties of MNs,the structure and function design of polymer MNs are systematically described in this review.And the materials and methods for the fabrication of polymer MNs and their drug administration are discussed as well.The recent progresses of MNs in anti-tumor,vaccine delivery,blood glucose regulation,tissue fluid extraction and detection are reviewed.The challenge of MNs technology is summarized and the future development trend of MNs is also prospected.
作者
曾志勇
江国华
刘天琦
张雪雅
孙延芳
Zhi-yong Zeng;Guo-hua Jiang;Tian-qi Liu;Xue-ya Zhang;Yan-fang Sun(College of Materials Science and Engineering,Zhejiang Sci-Tech University,Hangzhou 310018;International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers,Zhejiang Sci-Tech University,Hangzhou 310018;Zhejiang Mauritius Joint Research Center for Biomaterials and Tissue Engineering,Zhejiang Sci-Tech University,Hangzhou 310018;College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018)
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2022年第8期876-893,共18页
Acta Polymerica Sinica
基金
国家自然科学基金(基金号51873194)
浙江省自然科学基金(基金号LY18E030006)资助项目。
关键词
聚合物微针
抗肿瘤
疫苗递送
血糖调控
经皮给药
Polymer microneedles
Anti-tumor
Vaccine delivery
Blood glucose regulation
Transdermal drug delivery
