摘要
功能性消化不良(functional dyspepsia,FD)是一种常见的功能性胃肠病(functional gastrointestinal disorder,FGID),属于中医“痞满”“胃脘痛”范畴,多因“气机升降失常”所致。目前,FD发病机制主要涉及脑肠互动异常、胃容受性受损、内脏敏感性增高、胃动力不足、幽门螺杆菌感染、十二指肠异常、心理精神因素等。随着罗马Ⅳ标准的颁布,十二指肠的作用在FD的发病中日益凸显。十二指肠高敏性、十二指肠黏膜屏障受损及十二指肠黏膜低度炎症等在FD病理生理过程中起着非常重要的作用,十二指肠可能是治疗FD的新靶点。本文综述FD发病中十二指肠的作用及中医药研究,为FD的基础研究及临床治疗提供理论依据。
Functional dyspepsia(FD) is a common functional gastrointestinal disorder, which belongs to the category of "Pi man" and "Epigastric pain" in Traditional Chinese medicine, mostly due to the disorder Qi. At present, the pathogenesis of FD mainly involves abnormal brain-gut interaction, gastric receptivity damage, increased visceral sensitivity, insufficient gastric motility, helicobacter pylori infection, abnormal duodenum, psychological and psychiatric factors, etc. With the promulgation of the Rome Ⅳ, the role of duodenum in the pathogenesis of FD has become increasingly prominent. Duodenal hypersensitivity damage of duodenal mucosal barrier and low-grade inflammation of duodenal mucosa play a very important role in the physiopathologic of FD. The duodenum may be a new target for the treatment of FD. This article reviewed the mechanism of duodenal action in FD and TCM research, providing theoretical basis for the basic research and clinical treatment of FD.
作者
王丹
潘小丽
Wang Dan;Pan Xiaoli(College of Traditional Chinese Medicine,Chongqing Medical University,Chongqing 400042,China;Chongqing College of Traditional Chinese Medicine,Chongqing 402760,China;College of Acupuncture and Orthopedics,Hubei University of Traditional Chinese Medicine,Wuhan 430000,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2022年第3期925-932,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
湖北中医药大学“青苗计划”(2021ZZX009):基于NLRP3/caspase-1/GSDMD介导肠上皮细胞焦亡探讨电针足三里改善FD大鼠十二指肠炎症机制,负责人:潘小丽。
关键词
功能性消化不良
十二指肠
发病机制
中医
研究进展
Functional dyspepsia
Duodenum
Pathogenesis
Traditional Chinese medicine
Research progress
