摘要
目的探究精神分裂症患者血清视锥蛋白样蛋白-1(VILIP-1)、超氧化物歧化酶1(SOD-1)表达并探究其临床意义。方法选取在本院确诊的65例精神分裂症患者(疾病组)及同期在本院体检的65例健康者(健康组)作为研究对象。以酶联免疫吸附法检测血清VILIP-1、SOD-1、降钙素原(PCT)水平,以Pearson法分析精神分裂症患者血清VILIP-1、SOD-1水平表达与PCT水平的关系及两者间的相关性。再以ROC曲线下面积评估VILIP-1、SOD-1诊断精神分裂症的价值,以多因素Logistic回归分析影响精神分裂症发生的危险因素。结果疾病组血清VILIP-1、SOD-1、PCT水平高于健康组,差异有统计学意义(P<0.05)。血清VILIP-1、SOD-1、PCT表达与BPRS总分、敌对性、激活性、思维障碍、缺乏活力、焦虑抑郁各项评分均呈正相关(P<0.05)。精神分裂症患者血清VILIP-1、SOD-1表达水平与PCT均呈正相关(r=0.643,0.557,P<0.05)。血清VILIP-1、SOD-1水平的ROC曲线下面积分别为0.773、0.712,VILIP-1的特异度优于SOD-1,SOD-1的敏感度优于VILIP-1。两者联合检测ROC曲线下面积为0.911,特异度均优于单独检测。VILIP-1>586.51 pg/mL、SOD-1>6.25μg/L为影响精神分裂症发生的独立危险因素(P<0.05)。结论精神分裂症患者血清VILIP-1、SOD-1水平呈高表达,两者与炎症反应均呈正相关,可能参与疾病进展,为影响精神分裂症发生的独立危险因素,可能为诊断精神分裂症的潜在指标。
Objective To explore the expression of serum visinin-like protein-1(VILIP-1)and superoxide dismutase-1(SOD-1)in patients with schizophrenia and explore their clinical significance.Methods Sixty-five patients with schizophrenia(disease group)diagnosed in this hospital and 65 healthy people(healthy group)who received physical examination in this hospital during the same period were selected as the research objects.Enzyme-linked immunosorbent assay was used to detect levels of serum VILIP-1,SOD-1,and procalcitonin(PCT),Pearson method was used to analyze the relationship between serum levels of VIILIP-1,SOD-1 and PCT levels in patients with schizophrenia and the correlation between the two.The area under the ROC curve was used to evaluate the value of VILIP-1 and SOD-1 in diagnosing schizophrenia,multivariate Logistic regression was used to analyze the risk factors that affected the occurrence of schizophrenia.Results The serum levels of VILIP-1,SOD-1 and PCT in the disease group were higher than those in the healthy group,and the difference was statistically significant(P<0.05).Serum VILIP-1,SOD-1,and PCT expressions were positively correlated with BPRS total score,hostility,activation,thinking disorder,lack of energy,anxiety,and depression scores(P<0.05).The expression levels of serum VILIP-1 and SOD-1 in patients with schizophrenia were positively correlated with PCT(r=0.643,0.557,P<0.05).The areas under the ROC curve of serum VILIP-1 and SOD-1 levels were 0.773 and 0.712,respectively.The specificity of VILIP-1 was better than that of SOD-1,and the sensitivity of SOD-1 was better than that of VILIP-1.The area under the ROC curve of the combined detection of the two was 0.911,and the specificity was better than that of the single detection.VILIP-1>586.51 pg/m L and SOD-1>6.25μg/L were independent risk factors for schizophrenia(P<0.05).Conclusion The serum levels of VILIP-1 and SOD-1 are highly expressed in patients with schizophrenia,and both of which are positively correlated with inflammation.They may be involved in disease progression.They are independent risk factors affecting the occurrence of schizophrenia and may be potential indicators for the diagnosis of schizophrenia.
作者
马淑君
林育波
吴映娥
纪晓斌
郑闻华
MA Shujun;LIN Yubo;WU Yinge;JI Xiaobin;ZHENG Wenhua(Department of Psychiatry,the Fourth People's Hospital of Shantou,Shantou,Guangdong,China,515041;Department of Laboratory Medicine,the First Affiliated Hospital of Shantou University,Guangdong,China,515041)
出处
《分子诊断与治疗杂志》
2022年第8期1375-1378,1384,共5页
Journal of Molecular Diagnostics and Therapy
基金
汕头市科技计划医疗卫生类别项目(191030115264208)。
