摘要
目的 探究丙戊酸钠联合咪达唑仑治疗小儿惊厥性癫痫持续状态(CSE)的效果。方法 根据随机数字表法将56例CSE患儿分为对照组和观察组,各28例。在对症支持治疗基础上,对照组采取反复咪达唑仑治疗,观察组采取丙戊酸钠联合咪达唑仑治疗。比较两组的临床治疗效果。结果 观察组的治疗总有效率显著高于对照组(P<0.05)。观察组的药物起效时间及癫痫控制时间均短于对照组(P<0.05)。治疗后,观察组的神经元特异性烯醇化酶(NSE)和S-100β蛋白水平均明显低于对照组(P<0.05)。两组的药物不良反应总发生率无明显差异(P>0.05)。观察组的后遗症总发生率明显低于对照组(P<0.05)。结论 丙戊酸钠联合咪达唑仑治疗小儿CSE安全、有效,能够快速控制临床症状,减轻脑组织损伤,降低后遗症发生率。
Objective To explore the effect of sodium valproate combined with midazolam on convulsive status epilepticus(CSE) in children.Methods Fifty-six CSE children were divided into control group and observation group according to the random number table method,with 28 cases in each group.On the basis of symptomatic support treatment,the control group was treated with repeated midazolam,and the observation group was treated with sodium valproate combined with midazolam.The clinical therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P0.05).The total incidence of sequelae in the observation group was significantly lower than that in the control group(P <0.05).Conclusion Sodium valproate combined with midazolam in the treatment of CSE children is safe and effective,which can quickly control clinical symptoms,reduce brain tissue damage and decrease the incidence of sequelae.
作者
杨琳东
呼旭东
YANG Lindong;HU Xudong(Yan'an People's Hospital,Yan'an 716000;the People's Hospital of Yanchuan County,Yan'an 717200,China)
出处
《临床医学研究与实践》
2022年第24期90-92,共3页
Clinical Research and Practice
