摘要
目的探讨苏黄止咳胶囊联合茶碱缓释片治疗哮喘急性发作的临床效果。方法选取2018年8月—2021年8月平煤神马医疗集团总医院收治的86例哮喘急性发作患者,运用随机数字表法分成对照组和治疗组,每组各43例。对照组口服茶碱缓释片,1片/次,2次/d。治疗组在对照组基础上口服苏黄止咳胶囊,3粒/次,3次/d。两组患者均治疗14 d。观察两组临床疗效,比较治疗前后两组患者主要临床症状消失时间,肺通气功能、哮喘控制测试(ACT)问卷评分和简易版哮喘生活质量调查问卷(mini AQLQ)评分,呼出气一氧化氮(FeNO)和血清白细胞介素-33(IL-33)、C反应蛋白(CRP)、血管内皮生长因子(VEGF)水平。结果治疗后,治疗组总有效率比对照组显著提高(95.35%vs 81.40%,P<0.05)。治疗后,治疗组各项临床症状的消失时间较对照组均显著缩短(P<0.05)。治疗后,两组第1秒用力呼气容积百分比(FEV1%)、呼气峰流速百分比(PEF%)、ACT问卷评分和mini AQLQ评分均显著高于治疗前(P<0.05),且治疗组的改善更显著(P<0.05)。治疗后,两组Fe NO和血清IL-33、CRP、VEGF水平均显著低于治疗前(P<0.05),且治疗组降低更显著(P<0.05)。结论苏黄止咳胶囊联合茶碱缓释片治疗哮喘急性发作的整体疗效满意,可安全有效地控制哮喘症状、改善肺通气功能及提高生活质量。
Objective To investigate the clinical effect of Suhuang Zhike Capsules combined with Theophylline Sustained-release Tablets in treatment of acute asthma attacks.Methods Patients(86 cases)with acute asthma attacks in General Hospital of Pingmei Shenma Group from August 2018 to August 2021 were divided into control and treatment group by random number table,and each group had 43 cases.Patients in the control group were po administered with Theophylline Sustained-release Tablets,1 tablet/time,twice daily.Patients in the treatment group were po administered with Suhuang Zhike Capsules on the basis of the control group,3 grains/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluation was evaluated,the disappearance time of main clinical symptoms,pulmonary ventilation function,ACT questionnaire scores and miniAQLQ scores,FeNO and serum IL-33,CRP,and VEGF levels in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was significantly higher than that of the control group(95.35%vs 81.40%,P<0.05).After treatment,the disappearance time of clinical symptoms in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the scores of FEV1%,PEF%,ACT questionnaire,and miniAQLQ in two groups were significantly higher than those before treatment(P<0.05),and the improvement in the treatment group was more significant(P<0.05).After treatment,the levels of FeNO and serum IL-33,CRP,and VEGF in two groups were significantly lower than those before treatment(P<0.05),especially in the treatment group(P<0.05).Conclusion The overall curative effect of Suhuang Zhike Capsules combined with Theophylline Sustained-release Tablets in treatment of acute asthma attacks is satisfactory,which can safely and effectively control asthma symptoms,improve pulmonary ventilation function and improve quality of life.
作者
张倩
白黎峰
郑院青
杨咪乐
ZHANG Qian;BAI Li-feng;ZHENG Yuan-qing;YANG Mi-le(Department of Respiratory and Critical Care Medicine,General Hospital of Pingmei Shenma Group,Pingdingshan 467000,China)
出处
《现代药物与临床》
CAS
2022年第6期1274-1278,共5页
Drugs & Clinic
基金
平顶山市科技计划项目(2019-152)。
关键词
苏黄止咳胶囊
茶碱缓释片
哮喘急性发作
肺通气功能
气道炎症
血管内皮生长因子
Suhuang Zhike Capsules
Theophylline Sustained-release Tablets
acute asthma attacks
lung ventilation function
airway inflammation
VEGF
