摘要
设计并合成了一种用于近红外光驱动的化学-光热治疗的上转换-铋纳米体系诊疗剂(UBDAs),其具有出色的光热转换能力(28.5%)和良好的生物相容性。同时,在980 nm近红外光的激发下,UBDAs能够发射紫外/可见光,用于促进光敏剂偶氮苯在介孔中的连续旋转-翻转运动,从而实现药物的可控释放,且利用近红外光激发能够有效避免传统紫外光对生物组织的副作用。光热实验表明,UBDAs杂化纳米体系在980 nm激光照射下具有良好的光热效应。此外,含有Tm和Bi元素的UBDAs有望用于上转换发光成像和X射线计算机断层成像,进而实现双模成像介导且单一近红外光激发的癌症化学疗法和光热疗法。该研究结果为诊断和协同增强抗肿瘤治疗的综合研究提供了新的思路。
A hybrid nanosystem of upconversion-bismuth integration(denoted as UBDAs)is designed and synthesized for near infrared(NIR)light-driven chemo-photothermal therapy.The obtained UBDAs present excellent photothermal conversion capacity(~28.5%)and good biocompatibility.Meanwhile,under excitation of NIR,UBDAs can emit ultraviolet/visible light,which promotes the continuous rotation-flip movement of the photosensitizer azobenzene in the mesoporous,thereby achieving the controlled drug release and avoiding the side effects of traditional ultraviolet light excitation on biological tissues.Photothermal experiments show that UBDAs hybrid nanosystems have a good photothermal effect under 980 nm laser irradiation.In addition,based on Tm3+and Bi element the UBDAs are expected to be used in upconversion luminescence and X-ray computed tomography(CT)imaging to achieve dual-mode imaging-mediated and single NIR-driven chemotherapy and photothermal therapy.Therefore,this work provides a new idea for the integration of diagnosis and synergistically enhanced antitumor therapy.
作者
涂港
凌丹萍
刘杰
汪丰
王海芳
施利毅
孙丽宁
TU Gang;LING Dan-ping;LIU Jie;WANG Feng;WANG Hai-fang;SHI Li-yi;SUN Li-ning(Research Center of Nano Science and Technology,College of Sciences,Shanghai University,Shanghai 200444,China;Department of Chemistry,College of Sciences,Shanghai University,Shanghai 200444,China;Institute of Nanochemistry and Nanobiology,Shanghai University,Shanghai 200444,China)
出处
《发光学报》
EI
CAS
CSCD
北大核心
2022年第7期1040-1051,共12页
Chinese Journal of Luminescence
基金
国家自然科学基金(51872183)
上海市教育委员会和上海市教育发展基金会“曙光计划”(19SG38)资助项目。
关键词
上转换发光
成像
光热治疗
药物释放
杂化纳米体系
upconversion luminescence
imaging
photothermal therapy
drug release
hybrid nanosystems
