摘要
目的探讨冠心病患者中性粒细胞与淋巴细胞比值(NLR)、血清骨形态发生蛋白4(BMP4)和血管生成素样蛋白8(ANGPLT8)水平检测的临床意义。方法选择2019年1月至2021年6月73例因胸痛于该院心血管内科治疗的冠心病患者纳入冠心病组。选择同期主诉为胸痛于该院就诊的116例疑似冠心病患者为对照组。比较两组研究对象体质量指数(BMI)、吸烟史、饮酒史、糖尿病病史、高血压病史、心血管疾病家族病史等一般资料,检测并比较两组NLR、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、BMP4和ANGPLT8水平。对所有患者行冠状动脉造影检查,采用Gensini积分法评估冠状动脉病变程度,采用Logistic回归分析影响患者冠心病发病和严重程度的危险因素。结果冠心病组BMI、NLR、TG、BMP4、ANGPLT8水平,有吸烟史、饮酒史、高血压病史、糖尿病病史的患者人数比例均明显高于对照组,冠心病组HDL-C水平明显低于对照组,差异均有统计学意义(P<0.05)。NLR、BMP4、ANGPLT8及Gensini积分在单支病变组、双支病变组、三支病变组依次升高,两两比较,差异有统计学意义(P<0.05)。重度冠状动脉病变组NLR、BMP4、ANGPLT8水平均明显高于轻度冠状动脉病变组,差异有统计学意义(P<0.05)。HDL-C降低,TG、NLR、BMP4、ANGPLT8升高是影响冠心病发病的独立危险因素(P<0.05);NLR、BMP4、ANGPLT8升高是影响冠心病严重程度的独立危险因素(P<0.05)。结论NLR、BMP4、ANGPLT8是冠心病发病和严重程度的独立危险因素,NLR、BMP4、ANGPLT8检测有助于冠心病早期诊断及病情预测。
Objective To investigate the clinical significance of neutrophil to lymphocyte ratio(NLR),serum bone morphogenetic protein 4(BMP4)and angiogenin-like protein 8(ANGPLT8)in patients with coronary heart disease(CHD).Methods A total of 73 CHD patients treated in the Department of Cardiovascular Medicine of Yan′an University Xianyang Hospital from January 2019 to June 2021 were included in the CHD group.A total of 116 patients with suspected CHD who complained of chest pain were selected as the control group.Body mass index(BMI),smoking history,drinking history,history of diabetes,history of hypertension,family history of cardiovascular disease and other general information were compared between the two groups.The levels of NLR,total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglyceride(TG),BMP4 and ANGPLT8 were detected and compared between the two groups.All patients underwent coronary angiography,Gensini score was used to evaluate the degree of coronary artery disease,Logistic regression was used to analyze the factors affecting the incidence and severity of CHD.Results The BMI,the levels of NLR,TG,BMP4,ANGPLT8,the proportion of patients with smoking history,drinking history,hypertension history and diabetes history in CHD group were significantly higher than those in control group,and HDL-C level in CHD group was significantly lower than that in control group,the differences were statistically significant(P<0.05).The NLR,BMP4,ANGPLT8 and Gensini score increased in the order of single-vessel group,the double-vessel group and the triple-vessel group,the differences were statistically significant(P<0.05).The NLR,BMP4 and ANGPLT8 in severe coronary artery disease group were significantly higher than those in mild coronary artery disease group,the differences were statistically significant(P<0.05).The decrease of HDL-C and the increase of TG,NLR,BMP4 and ANGPLT8 were independent risk factors of CHD(P<0.05).The increase of NLR,BMP4 and ANGPLT8 were independent risk factors affecting the severity of CHD(P<0.05).Conclusion NLR,BMP4 and ANGPLT8 are independent factors influencing the incidence and severity of CHD.The levels of NLR,BMP4 and ANGPLT8 might help early diagnosis of CHD and disease status prediction.
作者
于艳华
谢文瑞
YU Yanhua;XIE Wenrui(Department of Clinical Laboratory,Yan′an University Xianyang Hospital,Xianyang,Shaanxi 712000,China)
出处
《检验医学与临床》
CAS
2022年第14期1961-1965,共5页
Laboratory Medicine and Clinic
