摘要
目的 探讨多囊卵巢综合征(PCOS)患者血清炎症因子及性激素水平的变化及二甲地黄汤的作用。方法 选取2018年1月~2020年6月浙江省丽水市中医院妇产科门诊治疗的PCOS患者40例作为试验组。试验组患者予以二甲地黄汤治疗,1剂/d,连用3个月经周期。观察试验组治疗前后血清炎症因子[超敏C反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)]及性激素[促卵泡生成素(FSH)、雌激素(E;)和促黄体生成素(LH)]水平的变化。另选择同期笔者医院体检中心的健康体检者30例作为对照组,对照组仅在纳入时测定血清hs-CRP、TNF-α、LH、FSH和E;水平。结果 试验组血清hs-CRP和TNF-α水平显著高于对照组,差异有统计学意义(P<0.01);试验组血清LH水平明显高于对照组,血清FSH和E;水平明显低于对照组,差异有统计学意义(P<0.05)。治疗3个月经周期后,试验组血清hs-CRP和TNF-α水平较治疗前明显下降,差异有统计学意义(P<0.01);试验组血清LH水平较前明显下降,血清FSH和E;水平较前明显上升,差异有统计学意义(P<0.05)。结论 PCOS患者存在血清炎症因子水平异常和性激素紊乱。二甲地黄汤治疗PCOS患者不仅可降低血清炎症因子水平,控制炎症反应,而且可纠正内分泌紊乱,调节性激素水平。
Objective To explore the changes of serum inflammatory factors and sex hormone levels in patients with polycystic ovary syndrome(PCOS) and the effect of Dijiadihuang Decoction. Methods A total of 40 PCOS patients treated in the Obstetrics and Gynecology Department of Lishui Traditional Chinese Medicine Hospital from January 2018 to June 2020 were selected as the experimental group. The patients in experimental group were treated with Erjiadihuang Decoction, 1 dose/d, for 3 consecutive menstrual cycles. The changes of serum inflammatory factors [hypersensitive Creactive protein(hs-CRP) and tumor necrosis factor-α(TNF-α)] and sex hormones [follicle stimulating hormone(FSH),estrogen(E;) and luteinizing hormone [LH] in experimental group before and after treatment] levels. In the same period,30 healthy subjects from the physical examination center of our hospital were selected as the control group, the serum hs-CRP, TNF-α, LH, FSH and E;levels were examined including in the study. Results The serum hs-CRP and TNF-α levels of patients in experimental group were significantly higher than those in control group, and the difference was statistically significant between two groups(P<0.01);the serum LH level of patients in experimental group was significantly higher than that in control group, and the serum FSH and E;levels of patients in were significantly lower than that in control group, the difference was statistically significant between two groups(P<0.05). After treatment for 3 menstrual cycles, the levels of serum hs-CRP and TNF-α in experimental group were significantly lower than before treatment, the difference was statistically significant before and after treatment(P<0.01);the levels of serum LH in experimental group were significantly lower than before, and the levels of serum FSH and E;were significantly higher than before, and the difference was statistically significant before and after treatment(P <0.05). Conslusion Patients with PCOS have abnormal levels of serum inflammatory factors and disorders of sex hormones. Erjiadihuang Decoction in the treatment of PCOS patients can not only reduce the level of serum inflammatory factors and control the inflammatory response, but also correct endocrine disorders and regulate the level of sex hormones.
作者
林群
徐丽霞
陈青华
石明晴
LIN Qun;XU Lixia;CHEN Qinghua;SHI Mingqing(Department of Laboratory,Lishui Hospital of Traditional Chinese Medicine in Zhejiang Province,Lishui 323000,China;Department of Obstetrics and Gynecology,Lishui Hospital of Traditional Chinese Medicine in Zhejiang Province,Lishui 323000,China)
出处
《中国现代医生》
2022年第16期124-127,共4页
China Modern Doctor
基金
浙江省卫生健康科技计划项目(2021RC147)。
关键词
多囊卵巢综合征
炎症因子
性激素
二甲地黄汤
Polycystic ovary syndrome
Inflammatory factors
Sex hormones
Dimethyl Dihuang Decoction
