摘要
目的探讨DNA双链断裂修复基因XRCC5、LIG4的多态性与脑胶质瘤的相关性。方法以126例脑胶质瘤患者以及120例健康志愿者作为研究对象,检测XRCC5基因rs828704、rs9288516位点以及LIG4基因rs3093737、rs3093739、rs10131位点的多态性,分析其与脑胶质瘤易感性的关系。结果XRCC5基因rs828704、rs9288516位点及LIG4基因rs3093737、rs3093739、rs10131位点在两组的分布均满足Hardy-Weinberg平衡(P>0.05)。病例组XRCC5基因rs9288516位点的A等位基因、LIG4基因rs10131位点的T等位基因频率高于对照组(P<0.05)。XRCC5基因rs9288516位点、LIG4基因rs10131位点在显性模型及加性模型下与胶质瘤易感性具有相关性(P<0.05);LIG4基因rs3093739位点在显性模型下与胶质瘤的易感性相关(P<0.05)。结论XRCC5基因rs9288516位点、LIG4基因rs10131位点与胶质瘤的易感性存在相关性。
Objective To assess the association of DNA double-strand break repair genes XRCC5 and LIG4 with glioma.Methods 126 patients with glioma(case group)and 120 healthy volunteers(control group)were enrolled.The polymorphisms of XRCC5 loci rs828704 and rs9288516,LIG4 loci rs3093737,rs3093739 and rs10131 were detected,and their association with the susceptibility to glioma was analyzed.Results Hardy-Weinberg test showed that XRCC5 loci rs828704 and rs9288516,LIG4 loci rs3093737,rs3093739 and rs10131 were in equilibrium in both groups(P>0.05).The frequency of A allele of XRCC5 gene rs9288516 locus and T allele of LIG4 gene rs10131 locus in the case group was higher than that in the control group(P<0.05).XRCC5 rs9288516 and LIG4 rs10131 were associated with the susceptibility to glioma under both recessive and additive models(P<0.05),while LIG4 rs3093739 was associated with susceptibility to glioma under the recessive model(P<0.05).Conclusion XRCC5 rs9288516 and LIG4 rs10131 are associated with the susceptibility to glioma.Above finding may provide a reference for the prevention and treatment of glioma.
作者
贺鹏
李冉
罗文凯
孟令松
He Peng;Li Ran;Luo Wenkai;Meng Lingsong(Department of Neurosurgery,Anyang People’s Hospital,Anyang,Henan 455000,China;Department of Imaging Diagnosis,the First People’s Hospital of Shangqiu,Shangqiu,Henan 476000,China)
出处
《中华医学遗传学杂志》
CAS
CSCD
2022年第6期641-645,共5页
Chinese Journal of Medical Genetics
基金
河南省医学科技攻关计划项目 (2018020943)。
