摘要
目的观察脾胃康颗粒口服联合中药热敷辅助治疗小儿轮状病毒(rotavirus,RV)感染性腹泻脾虚湿热证的临床疗效。方法选取2019年1—12月广东省第二中医院儿科收治的RV感染性腹泻脾虚湿热证患儿80例,采用随机数字表法分为对照组和治疗组,各40例。对照组口服补液盐Ⅲ和蒙脱石散,治疗组在对照组治疗方法的基础上予脾胃康颗粒口服和中药热敷治疗,2组均连续治疗5 d后统计临床疗效。结果治疗组总有效率为97.50%(39/40),明显高于对照组的77.50%(31/40),2组比较,差异有统计学意义(P<0.05)。治疗前,2组中医证候评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组中医证候评分均明显下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗组止泻时间明显短于对照组,RV转阴率明显高于对照组,2组比较,差异均有统计学意义(P<0.05)。治疗前,2组血清白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组IL-1β和IL-6水平均明显降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。结论脾胃康颗粒口服联合中药热敷辅助治疗RV感染性腹泻脾虚湿热证,不仅能够显著改善患儿临床症状、缩短止泻时间和病程,还能降低血清IL-1β、IL-6水平,提高RV转阴率,值得临床推广应用。
Objective To observe the clinical efficacy of oral administration of Piweikang Keli(脾胃康颗粒)combined with Chinese materia medica(CMM)fomentation in adjuvant treatment of pediatric rotavirus(RV)-induced diarrhea with damp-heat due to spleen-asthenia syndrome.Methods From January to December in 2019,80 cases of pediatric RV-induced diarrhea with damp-heat due to spleen-asthenia syndrome admitted into pediatrics department of Guangdong Second Hospital of TCM were divided into control group and treatment group according to random number table method,with 40 cases in each group.The control group was given oral rehydration saltsⅢand dictahedral smectite powder,on this basis,the treatment group was given oral administration of Piweikang Keli and CMM fomentation.We kept statistics about the clinical efficacy after the 2 groups were continuously treated for 5 days.Results The total effective rate of the treatment group was 97.50%(39/40),which was significantly higher than 77.50%(31/40)of the control group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the differences was not statistically significant in TCM syndrome scores between the 2 groups(P>0.05),indicating comparability.After treatment,TCM syndrome scores in the 2 groups significantly decreased,and the difference was statistically significant than those in the same group before treatment(P<0.05),moreover,the decrease was more significant in the treatment group(P<0.05).The time of stopping diarrhea in the treatment group was significantly shorter than that in the control group,the negative conversion ratio of RV therein was significantly higher than that in the control group,and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the differences were not statistically significant in serum levels of interleukin-1β(IL-1β)and interleukin-6(IL-6)between the 2 groups(P>0.05),indicating comparability.After treatment,the levels of IL-1βand IL-6 in the 2 groups all significantly decreased,and the differences were statistically significant than those in the same group before treatment(P<0.05),moreover,the decrease was more significant in the treatment group(P<0.05).Conclusion It can not only markedly alleviate the clinical symptom,shorten the time of stopping diarrhea and course of disease,but also decrease the serum levels of IL-1βand IL-6,improve the negative conversion ratio of RV to orally administer Piweikang Keli combined with CMM fomentation in adjuvant treatment of pediatric RV-induced diarrhea with damp-heat due to spleen-asthenia syndrome,which deserves clinical promotion and application.
作者
徐嘉辉
张畅
陈丽君
林晓洁
XU Jiahui;ZHANG Chang;CHEN Lijun;LIN Xiaojie(Department of Pediatrics,Guangdong Second Hospital of TCM,Guangzhou,Guangdong,510000,China;Department of Pediatrics,The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong,510000,China)
出处
《中医儿科杂志》
2022年第3期49-53,共5页
Journal of Pediatrics of Traditional Chinese Medicine
基金
广东省中医药局科研项目(20181036)。
关键词
轮状病毒感染性腹泻
小儿
脾虚湿热证
脾胃康颗粒
中药热敷
临床观察
rotavirus(RV)-induced diarrhea
children
damp-heat due to spleen-asthenia syndrome
Piweikang Keli(脾胃康颗粒)
Chinese materia medica(CMM)fomentation
clinical observation
