摘要
目的 探讨对急性冠状动脉综合征患者分别采用琥珀酸美托洛尔缓释片以及酒石酸美托洛尔片药物完成治疗后获得临床效果。方法 选取2017年1月至2019年5月山东省枣庄市皮肤病性病防治院收治的62例急性冠状动脉综合征患者进行药物治疗研究,随机分为酒石酸美托洛尔组(采用酒石酸美托洛尔片进行治疗)和琥珀酸美托洛尔组(采用琥珀酸美托洛尔缓释片进行治疗),每组各31例;比较两组患者心绞痛治疗总有效率、心率收缩压乘积、心肌耗氧量、收缩压水平、心率水平。结果 琥珀酸美托洛尔组心绞痛治疗总有效率(93.55%)高于酒石酸美托洛尔组(61.29%),差异有统计学意义(P<0.05);治疗后,琥珀酸美托洛尔组心率收缩压乘积(8084.96±1372.19)低于酒石酸美托洛尔组心率收缩压乘积(8941.63±902.12),差异有统计学意义(P<0.05);治疗后,琥珀酸美托洛尔组心肌耗氧量[(8084.96±1255.52)次/(min·mmHg)]低于酒石酸美托洛尔组心肌耗氧量[(8642.63±902.12)次/(min·mmHg)],差异有统计学意义(P<0.05);治疗后,琥珀酸美托洛尔组收缩压[(117.95±11.26)mmHg]低于酒石酸美托洛尔组收缩压[(127.09±9.75)mmHg],差异有统计学意义(P<0.05);治疗后,琥珀酸美托洛尔组心率[(69.26±5.07)次/min]低于酒石酸美托洛尔组心率[(76.62±8.02)次/min],差异有统计学意义(P<0.05)。结论 琥珀酸美托洛尔缓释片有效应用后,同酒石酸美托洛尔片比较,可显著改善患者心绞痛治疗总有效率、心率收缩压乘积、心肌耗氧量、收缩压水平、心率水平,可促进急性冠状动脉综合征患者总体用药效果、预后效果双重提升。
Objective To investigate the clinical effects of metoprolol succinate sustained release tablets and metoprolol tartrate tablets in patients with acute coronary syndrome. Methods A total of 62 patients with acute coronary syndrome who were admitted from January 2017 to May 2019 in Zaozhuang Dermatology And Venereal Disease Prevention And Treatment Hospital in Shandong Province were selected for the drug therapy study. They were randomly divided into the metoprolol tartrate group, in which the patients were treated with metoprolol tartrate tablets, and the metoprolol succinate group, in which the patients were treated with metoprolol succinate sustained release tablets, with 31 patients in each group. The total effective rate, rate-pressure product, cardiac oxygen consumption, systolic blood pressure level and heart rate level were compared between the two groups. Results The total effective rate of the metoprolol succinate group(93.55%) was higher than that of the metoprolol tartrate group(61.29%), and the difference was statistically significant(P<0.05). After treatment, the rate-pressure product of the metoprolol succinate group(8084.96 ±1372.19) was lower than that of the metoprolol tartrate group(8941.63±902.12), and the difference was statistically significant(P<0.05).After treatment, the myocardial oxygen consumption of the metoprolol succinate group([8084.96±1255.52] times/[min·mmHg]) was lower than that of the metoprolol tartrate group([8642.63±902.12] times/[min·mmHg]), and the difference was statistically significant(P <0.05). After treatment, the systolic blood pressure of the metoprolol succinate group([117.95±11.26] mmHg) was lower than that of the metoprolol tartrate group([127.09±9.75] mmHg), and the difference was statistically significant(P<0.05). After treatment, the heart rate of the metoprolol succinate group([69.26 ±5.07]times/min) was lower than that of the metoprolol tartrate group([76.62±8.02] times/min), and the difference was statistically significant(P <0.05). Conclusion After effective application of metoprolol succinate sustained release tablets,compared with metoprolol tartrate tablets, the total effective rate in the treatment of angina pectoris, rate-pressure product, myocardial oxygen consumption, systolic blood pressure level and heart rate level can be significantly improved, which can promote the overall medication effect and prognosis effect of patients with acute coronary syndrome.
作者
赵翔猛
ZHAO Xiangmeng(Department of Internal Medicine,Zaozhuang Dermatology And Venereal Disease Prevention And Treatment Hospital in Shandong Province,Zaozhuang277599,China)
出处
《中国现代医生》
2022年第10期127-130,共4页
China Modern Doctor
关键词
急性冠状动脉综合征
琥珀酸美托洛尔缓释片
酒石酸美托洛尔片
心绞痛治疗总有效率
心率收缩压乘积
心肌耗氧量
收缩压水平
心率水平
Acute coronary syndrome(ACS)
Metoprolol succinate sustained release tablet
Metoprolol tartrate tablet
Total effective rate of angina pectoris treatment
Rate-pressure product
Myocardial oxygen consumption
Systolic blood pressure level
Heart rate level
