摘要
目的观察金振口服液联合甲泼尼龙治疗儿童难治性肺炎支原体肺炎(RMPP)临床疗效及对肺功能的影响。方法将我院收治的96例RMPP患儿(风热犯肺证)随机分为观察组与对照组各48例。对照组给予甲泼尼龙辅助治疗,观察组在对照组的治疗基础上联合金振口服液治疗,比较两组患儿临床疗效、临床症状、肺功能、炎性指标、不良反应发生情况。结果治疗后两组临床治疗总有效率比较差异不显著(P>0.05);观察组咳嗽、咳痰、喘息、肺部体征、发热、鼻塞、流涕、咽部充血症状积分低于对照组(P<0.05);观察组肺功能指标1秒用力呼气末容积(FEV1)、最大呼气中期流速(MMF)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)、最大呼气流速(PEF)水平高于对照组(P<0.05);观察组血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平低于对照组(P<0.05);两组不良反应发生率比较有显著性差异(P>0.05)。结论金振口服液联合甲泼尼龙治疗儿童RMPP可有效改善患儿临床症状,提高肺功能水平,减轻炎症反应,疗效显著,安全性高。
Objective To observe the clinical curative effect of Jinzhen Oral Liquid combined with methylprednisolone on children with refractory Mycoplasma pneumoniae pneumonia(RMPP)and its influences on pulmonary function.Methods Ninety-six RMPP children(wind-heat invadinglung)were randomly divided into observation group and control group,48 cases each.Control group was given adjuvant treatment of methylprednisolone,while observation group was additionally given Jinzhen Oral Liquid.The toal clinical curative effect,clinical symptoms,pulmonary function,inflammatory indexes and occurrence of adverse reactions were compared between the two groups.Results There was no significant difference in response rate of clinical treatment between the two groups(P>0.05).After treatment,scores of cough,expectoration,wheezing,pulmonary signs,fever,nasal congestion,rhinorrhoea and pharyngeal congestion in observation group were lower than those in control group(P<0.05);levels of pulmonary function indexes(forced expiratory volume in 1 second(FEV1),maximum mid-expiratory flow rate(MMF),FEV 1/forced vital capacity(FEV1/FVC),peak expiratory flow(PEF))in observation group were higher than those in control group(P<0.05);levels of serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high-sensitivity C-reactive protein(hs-CRP)in observation group were lower than those in control group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Jinzhen Oral Liquid combined with methylprednisolone can effectively improve their clinic al symptoms andpulmonary function level and alleviate inflammation reactions in treatment of children with RMPP,with significant curative effect and high safety.
作者
刘雪莲
李文联
LIU Xue-lian;LI Wen-lian(Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine,Zhuhai 519020)
出处
《湖北中医药大学学报》
2022年第2期27-30,共4页
Journal of Hubei University of Chinese Medicine
基金
广东省珠海市科技计划项目(项目编号:02660111140625024)。
关键词
儿童难治性肺炎
支原体肺炎
甲泼尼龙
金振口服液
肺功能
Refractory pneumonia in child
Mycoplasma pneumonia
Methylprednisolone
Jinzhen Oral Liquid
Pulmonary function
