摘要
耐药菌已成为人类健康的严重威胁。多黏菌素对部分产生抗生素耐药的革兰阴性菌和革兰阳性菌显示出很强的杀菌活性,成为了对抗多种多药耐药菌的最后治疗选择。然而,由于多黏菌素在动物养殖中的滥用,导致其在人群中的耐药率明显升高。本文综述了多黏菌素抗菌的作用机制、人群耐药流行情况,以及耐药机制和耐药的传播方式等方面的研究进展,以期加深对多黏菌素耐药发生机制的理解,从而采取措施降低其在人群中耐药的发生率。
Drug-resistant bacteria have become a serious threat to human health.Polymyxin has shown strong bactericidal activity to some Gramnegative and Gram-positive bacteria that are resistant to antibiotics,and has become a last-resort treatment option against a variety of multi-drug resistant bacteria.However,due to the abuse of polymyxin in animal breeding,the drug resistance rate of polymyxin in human population has significantly increased.In order to further understand the mechanism of polymyxin resistance,and to take measures to reduce the incidence of polymyxin resistance in the population,this paper reviewed the progress in research of the antibacterial mechanism of polymyxin,the prevalence of polymyxin resistance in the population,the mechanism of polymyxin resistance,and its transmission mode.
作者
蔡家安
蒋露芳
姜庆五
CAI Jia’an;JIANG Lufang;JIANG Qingwu(School of Basic Medical Sciences,Hehai University,Shanghai 200032,China;School of Public Health,Hehai University,Shanghai 200032,China)
出处
《上海预防医学》
CAS
2022年第3期283-287,共5页
Shanghai Journal of Preventive Medicine
基金
国家自然科学基金国际(地区)合作与交流项目(81861138050)。
关键词
多黏菌素
耐药
耐药机制
耐药性的传播方式
质粒介导的黏菌素耐药
polymyxin
drug resistance
mechanism of polymyxin resistance
transmission mode of polymyxin resistance
plasmid-mediated polymyxin resistance
