摘要
目的评价蒙药枸杞子-7防治子宫内膜异位症复发的药理作用。方法以手术法制备子宫内膜异位症复发大鼠模型,以蒙药枸杞子-7灌胃治疗14 d,分别在给药第1、7、14 d测量异位包块大小,末次给药后麻醉处死大鼠,测定血清E2和P含量,观察子宫组织病理组织学变化。结果与空白组相比,模型组血清E2和P含量升高(P<0.05);与模型组相比,蒙药枸杞子-7组血清E2和P含量下降(P<0.05),病理学变化好转。结论蒙药枸杞子-7在14 d内可有效防治子宫内膜异位症复发。该研究为枸杞子进一步开发研究提供了坚实的工作基础。
Objective:To evaluate the pharmacological effects of Lycium barbarum-7 in the prevention and treatment of the recurrence of endometriosis.Methods:A rat model of recurrent endometriosis was prepared by surgery,and the rats were intragastrically treated with Lycium barbarum-7 for 14 days.The size of the ectopic mass was measured on the 1st,7th,and 14th day of administration,and the rats were sacrificed after anesthesia when the last administration was performed.Their serum E2 and P levels were determined and their histopathological changes in uterine tissue were observed.Results:Compared with the blank group,the serum E2 and P contents of the model group increased(P<0.05);compared with the model group,the serum E2 and P contents of the Lycium barbarum-7 group decreased(P<0.05),and the pathological changes improved.Conclusion:Lycium barbarum-7 can effectively prevent and treat the recurrence of endometriosis within 14 days.The study provides a solid working foundation for further development of wolfberry fruit.
作者
白梅荣
陈玉兰
乌日汉
萨出日拉
根玉
BAI Mei-rong;CHEN Yu-lan;WU Ri-han;Sachu Rila;GEN Yu(Key Laboratory of Mongolian Medicine Research and Development Engineering of Ministry of Education,Inner Mongolia University for Nationalities,Tongliao 028000,China;The Affiliated Hospital of Inner Mongolia University for Nationalities,Tongliao 028000,China)
出处
《云南中医中药杂志》
2022年第4期49-54,共6页
Yunnan Journal of Traditional Chinese Medicine and Materia Medica
基金
国家自然科学基金项目(81360674)
蒙药安全性评价创新团队建设项目(MY20190003)
蒙医药研发工程教育部重点实验室开放课题(MDK2019065)
中央支持地方建设专项资金交叉学科建设项目(JCHXKXM001)
蒙医药标准化国际科技合作项目子课题(MDKBZH2018028)。
关键词
蒙药
枸杞子-7
防治
子宫内膜异位症复发
实验研究
Mongolian Medicine
Lycium Barbarum-7
Prevention And Treatment
Recurrence Of Endometriosis
Experimental Study
