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Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition) 被引量：32

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摘要 Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC.
作者 Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无
机构地区 Department of Liver Surgery and Transplantation Department of Medical Oncology of PLA Cancer Center Department of Infectious Disease Department of Liver Surgery Minimally Invasive Interventional Division Department of Hepatobiliary Surgery Department of Radiation Oncology Department of Hepatobiliary and Pancreatic Surgery Department of Pathology Department of Liver Surgery Department of Hepatobiliary Surgery Department of Hepatobiliopancreatic Surgery Division of Hepatobiliary Surgery Department of Hepatobiliary and Splenic Surgery The Department of Hepatobiliary Oncology of Sun Yat-sen University Cancer Center Department of Hepatobiliary and Pancreatic Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Hepatobiliary Surgery Hepatic Surgery Center Department of Hepato-Biliary Pancreatic Surgery Department of Hepatobiliary Pancreatic Surgery Department of general surgery Department of Liver Transplantation Center Center of General Surgery Department of General Surgery The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Division of General Surgery Department of Hepatobiliary Surgery Department of Hepatobiliary Surgery Department of Interventional Radiology Department of Liver Surgery Department of Intervention Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Department of Hepatobiliary Cancer Department of Hepatobiliary Surgery Department of Hepatic-Biliary Surgery Department of Hepatobiliary Surgery Department of Hepatobiliary Surgery Department of Hepatobiliary and Pancreatic Surgery Liver Surgery Department Department of Hepatobiliary Surgery Department of Liver Surgery&Liver Transplantation Centre Hepatopancreatobiliary Surgery Department I Hepatobiliary Surgery Department Division of Hepatobiliary and Pancreatic Surgery Unit of Hepatobiliary Surgery Department of Intervention Department of Hepatic&Biliary&Pancreatic Surgery Department of Hepatobiliary Surgery Department of Hepatobiliary Surgery Department of Hepatobiliary Surgery Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province Department of Hepatic Surgery Department of Hepatobiliary Surgery Department of Hepatobiliary Pancreatic Surgery Department of Hepatobiliary Pancreatic Surgery Department of Liver Surgery Department of Liver Surgery Division of Hepatobiliary and Pancreatic Surgery Hepatoliliary Surgery Center Qinhuai Medical Area Department of Hepatic Surgery IV Department of General Surgery Center of Interventional Radiology and Vascular Surgery Department of Liver Surgery Department of Hepatobiliary Surgery Department of Hepatobiliary Surgery Department of Hepatobiliary and Pancreatic Surgery Department of Hepatobiliary and Pancreatic Surgery Hepatopancreatobiliary Center Hepatobiliary Center Division of Hepatobiliary and Pancreatic Surgery Alliance of Liver Cancer Conversion Therapy
出处 《Hepatobiliary Surgery and Nutrition》 SCIE 2022年第2期227-252,I0011-I0014,共30页 肝胆外科与营养（英文）
关键词 Hepatocellular carcinoma(HCC) conversion therapy surgical resection systematic treatment locoregional treatment CONSENSUS China
分类号 R73 [医药卫生—肿瘤]
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Hepatobiliary Surgery and Nutrition
2022年 第2期

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