摘要
目的观察吡仑帕奈在儿童药物难治性癫痫添加治疗中的临床疗效。方法收集2020年1月至6月在福建医科大学附属协和医院儿科门诊就诊并使用吡仑帕奈添加治疗的药物难治性癫痫患儿临床资料并进行回顾性分析,评估吡仑帕奈在儿童药物难治性癫痫添加治疗中的疗效。吡仑帕奈添加治疗前、后自身对照统计有效率。结果共计纳入2-12岁药物难治性癫痫患儿20例,其中男14例,女6例,年龄(5.82±2.39)岁,发病年龄(3.41±1.96)岁,病程(2.40±1.48)年。20例患儿中癫痫部分性发作1例,复杂部分性发作7例,全面性发作1例,未能明确发作6例,癫痫综合征5例。吡仑帕奈添加治疗3个月后,癫痫无发作者4例,发作频率减少>50%者8例,发作持续时间减少者2例,发作抽搐严重程度减少者1例,发作未见明显改善者4例,发作频率增加者1例。以癫痫发作频率减少≥50%为标准,吡仑帕奈添加治疗有效率为60%。结论第三代抗癫痫发作药物吡仑帕奈在2-12岁儿童药物难治性癫痫添加治疗中效果明显,并且特别适用于年长患儿复杂部分性发作及特定癫痫综合征。
Objective To observe the clinical effect of Perampanel on the add-on therapy in children with drug-resistant epilepsy.Methods Clinical data of children with drug-resistant epilepsy treated with add-on therapy of Perampanel in the Department of Pediatrics,Fujian Medical University Union Hospital from January to June 2020 were retrospectively analyzed,aiming to assess the therapeutic efficacy of Perampanel on the add-on therapy of drug-resistant epilepsy.The self-control effective rate of Perampanel before and after treatment were counted.Results A total of 20 cases of 2-12 year-old children with drug-resistant epilepsy were collected,including 14 males and 6 females.Their mean age,age of onset and course of disease were(5.82±2.39)years,(3.41±1.96)years and(2.40±1.48)years,respectively.Among them,1 case had simple partial seizures,7 cases had complex partial seizures,1 case had generalized seizures and 5 cases had epilepsy syndromes,there were 6 cases with undetermined seizure attack.After 3-month add-on therapy of Perampanel,4 cases of children with drug-resistant epilepsy were seizure-free,8 cases had the reduced frequency of seizure for 50%or more,2 cases had the reduced duration of seizure,1 case had the reduced severity of seizure,while 4 cases did not respond to perampanel and 1 case was aggravated.Based on the criteria of reduced frequency of seizure for more than 50%,the therapeutic efficacy of add-on therapy of Perampanel achieved 60%in children with drug-resistant epilepsy.Conclusions The third generation of anti-seizure medication Perampanel can effectively reduce the frequency of seizure,especially in the elder children and those with certain epilepsy syndromes.
作者
陈国锋
李国铭
柯钟灵
陈燕惠
Chen Guofeng;Li Guoming;Ke Zhongling;Chen Yanhui(Department of Pediatrics,Fujian Medical University Union Hospital,Fuzhou 350000,China)
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2022年第3期182-185,共4页
Chinese Journal of Applied Clinical Pediatrics
基金
国家重点研究发展计划项目(2016YF1306204)
福建省临床重点专科建设项目(闽卫医政(2015)593号)。
关键词
儿童
疗效观察
药物难治性癫痫
吡仑帕奈
Child
Observation on curative efficacy
Drug-resistant epilepsy
Perampanel
