摘要
麦冬是重要的滋阴药,有养阴生津、清心除烦的功效,并具有多种化学成分和药理作用,在临床应用十分广泛。科学知识图谱是可以定量、客观地展示学科研究的发展前沿和方向的有效工具。该研究搜集Web of Science(WoS)及中国知网(CNKI)与麦冬相关的中医药研究文献,采用科学计量学软件CiteSpace对文献中涉及的研究机构、期刊和关键词进行可视化分析,构建麦冬相关研究的共现网络,利用Cytoscape 3.8.2绘制麦冬-疾病-靶点网络图谱。并针对中、英文文献研究热点进行内容分析,讨论当前研究热点,总结麦冬研究中存在的不足,探讨其发展趋势。该研究最终纳入中文文献1403篇,英文文献292篇。发文机构分析显示北京中医药大学和中国药科大学分别为中、英文文献发文量最多的研究机构;发文期刊分析显示《河北中医》《Journal of Asian Natural Products Research(亚洲天然产物研究杂志)》是麦冬研究发文量最多的期刊;关键词分析显示中文文献侧重于用药规律及临床观察研究,英文文献侧重于成分测定及药理研究,其中数据挖掘和基于细胞凋亡的药理机制或仍为将来一段时间的研究方向。
Ophiopogonis Radix is an important Yin-nourishing drug in traditional Chinese medicine(TCM),with the effects of nourishing Yin,promoting fluid production,clearing away heart-fire,and relieving restlessness.It is widely used in clinical practice due to its multiple chemical components and pharmacological effects.The technique"mapping knowledge domains"is an effective tool to quantitatively and objectively visualize the development frontiers and trends of certain disciplines.In this study,TCM research papers related to Ophiopogonis Radix were retrieved from Web of Science(WoS)and CNKI,and the research institutions,journals,and keywords involved were visualized and analyzed using the scientometric software CiteSpace.The co-occurrence network of related research on Ophiopogonis Radix was constructed,and the Ophiopogonis Radix-disease-target network was plotted using Cytoscape 3.8.2.The hot topics in Chinese and English papers were analyzed and the shortcomings in the research on Ophiopogonis Radix were summed up.Furthermore,the development trends were discussed.A total of 1403 Chinese papers and 292 English papers were included in this study.The analysis of research institutions showed that Beijing University of Chinese Medicine and China Pharmaceutical University were the two research institutions with the largest numbers of papers published.The analysis of journals showed that Hebei Journal of Traditional Chinese Medicine and Journal of Asian Natural Products Research were the two journals with the highest numbers of papers concerning Ophiopogonis Radix.The keyword analysis showed that the research contents of Chinese papers focused on the analysis of medication regularity and clinical observation trials,while the English papers focused on component analysis and pharmacological investigation.Data mining and apoptosis-based pharmacological mechanism might be the research trends in the future.
作者
曾子玲
佟琳
刘思鸿
张磊
高宏杰
陈广坤
张华敏
ZENG Zi-ling;TONG Lin;LIU Si-hong;ZHANG Lei;GAO Hong-jie;CHEN Guang-kun;ZHANG Hua-min(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences y Beijing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第24期6549-6557,共9页
China Journal of Chinese Materia Medica
基金
国家重点研发计划项目(2018YFC1704401)
中央级公益性科研院所基本科研业务费专项(ZZ13-YQ-131,ZZ140310)。
