期刊文献+

套细胞淋巴瘤转化为WHSC1及NOTCH1等基因阳性的淋巴瘤细胞白血病1例报道并文献复习 被引量:2

在线阅读 下载PDF
导出
摘要 套细胞淋巴瘤(MCL)为非霍奇金淋巴瘤中B细胞淋巴瘤的一种少见类型,通常起病隐匿,占非霍奇金淋巴瘤的3%~8%。参考我国之前常用的WF分类标准,MCL属于恶性侵袭性淋巴瘤的一种,老年男性多见,疾病确诊时常已至晚期,发病时常伴有肝大及骨髓等其他器官及外周血侵犯,预后差且复发率较高。目前,临床上R-CHOP方案作为治疗MCL的一线药物多数可缓解病情,无完全规范化治疗MCL的方案^([1])。本院血液科收治了MCL转化为WHSC1及NOTCH1阳性的淋巴瘤白血病1例,现报道如下。
出处 《检验医学与临床》 CAS 2022年第6期862-864,共3页 Laboratory Medicine and Clinic
基金 甘肃省自然科学基金资助项目(20JR5RA595)。
  • 相关文献

参考文献10

二级参考文献41

  • 1Grabher C,von Boehmer H,Look AT.Notch 1activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia[J].Net Rev Cancer,2006,6:347-359.
  • 2Weng AP,Ferrando AA,Lee W,et al.Activating mutations of NOTCH1in human T cell acute lymphoblastic leukemia[J].Science,2004,306:269-271.
  • 3Mansour MR,Linch DC,Foroni L,et al.High incidence of Notch-1 mutations in adult patients with Tcell acute lymphoblastic[J].Leukemia,2006,20:537-539.
  • 4Breit S,Stanulla M,Flohr T,et al.Activating NOTCH1mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia[J].Blood,2006,108:1151-1157.
  • 5Park MJ,Taki T,Oda M,et al.FBXW7and NOTCH1mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma[J].Br J Haematol,2009,145:198-206.
  • 6Ferrando AA,Neuberg DS,Staunton J,et al.Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia[J].Cancer Cell,2002,1:75-87.
  • 7Ferrando AA,Neuberg DS,Dodge RK,et al.Prognostic importance of TLX1(HOX11)oncogene expression in adults with T-cell acute lymphoblastic leukaemia[J].Lancet,2004,363:535-536.
  • 8Baldus CD,Thibaut J,Goekbuget N,et al.Prognostic implications of NOTCH1and FBXW7mutations in adult acute T-lymphoblastic leukemia[J].Haematologica,2009,94:1383-1390.
  • 9Asnafi V,Buzyn A,Le Noir S,et al.NOTCH1/FBXW7mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia(T-ALL):a Group for Research on Adult Acute Lymphoblastic Leukemia(GRAALL)study[J].Blood,2009,113:3918-3924.
  • 10Mansour MR,Sulis ML,Duke V,et al.Prognostic implications of NOTCH1and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993protocol[J].J Clin Oncol,2009,27:4352-4356.

共引文献31

同被引文献32

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部