摘要
云南省宣威地区肺癌发病高居全国首位,是典型的空气污染相关肺癌。近年来宣威肺癌发病率持续快速增长,呈现出明显的家族聚集现象。宣威地区家族肺癌发病年龄提前,腺癌、多原发肺癌占比高,高血压、糖尿病及合并其他癌症情况多见,家族肺癌患者的驱动基因突变谱与遗传背景独特。宣威家族肺癌是研究环境、遗传与肺癌发生的理想对象,就云南省宣威地区家族肺癌研究进展作一综述。
The incidence of lung cancer in Xuanwei area of Yunnan Province ranks first in China,which is a typical air pollution related lung cancer.In recent years,Xuanwei lung cancer incidence rate continues to grow rapidly,showing a clear phenomenon of family aggregation.The incidence of lung cancer in the Xuanwei area is earlier than that of adenocarcinoma and multiple primary lung cancer.Hypertension,diabetes and other cancers are common.The gene mutation spectrum and genetic background of family lung cancer patients are unique.Xuanwei family lung cancer is an ideal object to study the environment,genetics and occurrence of lung cancer.This paper reviews the research progress of family lung cancer in Xuanwei area of Yunnan Province.
作者
何大千
宁明杰
陈颖
HE Daqian;NING Mingjie;CHEN Ying(The 3rd Affiliated Hospital of Kunming Medical University;The International Cooperation Key Laboratory of Regional Tumor in High Altitude Area,Kunming Yunnan 650118,China)
出处
《昆明医科大学学报》
CAS
2022年第3期135-141,共7页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(82060426,81702274)
云南省卫建委医学科学带头人培养计划资助项目(D-2018025)。
关键词
家族肺癌
空气污染
多原发肺癌
遗传易感性
Family lung cancer
Air pollution
Multiple primary lung cancer
Genetic susceptibility
