摘要
目的探讨对重症肺炎患者采用血必净联合纤维支气管镜治疗的临床效果及对血气指标以及炎症因子水平的影响。方法随机选择该院2020年1—12月收治的重症肺炎者80例,以随机数表法进行分组,采用常规用药与吸痰治疗的对照组(n=40)与采用血必净联合纤维支气管镜吸痰灌洗治疗的研究组(n=40),比较两组患者的临床疗效,检测治疗前后氧分压、二氧化碳分压、血氧饱和度,来评价患者血气指标状态,并检测治疗前后C反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子(TNF-α)水平,分析机体炎性反应。结果研究组总有效率为97.50%,高于对照组的75.00%,差异有统计学意义(χ^(2)=8.538,P<0.05)。治疗后研究组氧分压、血氧饱和度分别为(81.33±7.05)mmHg、(94.20±3.27)%,高于对照组;二氧化碳分压为(40.22±4.52)mmHg,低于对照组,差异有统计学意义(t=4.655、7.454、5.068,P<0.05)。治疗后研究组CRP、PCT、TNF-α水平分别为(26.11±6.46)mg/L、(0.62±0.25)pg/L、(50.25±6.40)ng/L,均低于对照组,差异有统计学意义(t=9.387、10.222、7.334,P<0.05)。结论对重症肺炎者,通过纤维支气管镜进行肺泡灌洗吸痰,并配合使用血必净注射液,可提高治疗效果,能够有效改善机体血气指标,有利于减轻机体炎性反应,值得推广。
Objective To investigate the clinical effect of Xuebijing combined with fiberoptic bronchoscopy in patients with severe pneumonia and its influence on blood gas indexes and inflammatory factor levels.Methods 80 cases of patients with severe pneumonia admitted and treated in the hospital from January to December 2020 were randomly selected and randomly divided into two groups with 40 cases in each,the control group were treated with routine medication and sputum suction,and the study group were treated with Xuebijing combined with fiberoptic bronchoscopy sputum suction and lavage,and the clinical efficacy of the two groups was compared.The oxygen partial pressure,carbon dioxide partial pressure and blood oxygen saturation were detected before and after treatment to evaluate the state of blood gas indexes,and the levels of C-reactive protein(CRP),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)were detected before and after treatment to analyze the inflammatory response of the body.Results The total effective rate of the study group was 97.50%,which was higher than 75.00%of the control group,and the difference was statistically significant(χ^(2)=8.538,P<0.05).After treatment,the oxygen partial pressure and blood oxygen saturation in the study group were(81.33±7.05)mmHg and(94.20±3.27)%,respectively,which were higher than those in the control group,the partial pressure of carbon dioxide was(40.22±4.52)mmHg,which was lower than that of the control group,and the difference was statistically significant(t=4.655,7.454,5.068,P<0.05).After treatment,the levels of CRP,PCT and TNF-αin the study group were(26.11±6.46)mg/L,(0.62±0.25)pg/L and(50.25±6.40)ng/L,respectively,which were lower than those in the control group,and the differences were statistically significant(t=9.387,10.222,7.334,P<0.05).Conclusion For patients with severe pneumonia,alveolar lavage and sputum suction through fiberoptic bronchoscopy,combined with Xuebijing injection,can improve the treatment effect and can effectively improve the body's blood gas indicators.It is beneficial to reduce the body's inflammatory response and is worthy of promotion.
作者
马文文
MA Wenwen(First Department of Respiratory and Critical Care Medicine,Jinxiang County People's Hospital,Jining,Shandong Province,272200 China)
出处
《中外医疗》
2022年第2期91-94,共4页
China & Foreign Medical Treatment
关键词
重症肺炎
血必净
纤维支气管镜
吸痰
灌洗
炎症因子
血气指标
Severe pneumonia
Xuebijing
Fiberoptic bronchoscopy
Sputum suction
Lavage
Inflammatory factors
Blood gas indicators
