摘要
结直肠癌是一种严重危害人类生命健康的恶性肿瘤,由于现代社会的饮食结构和生活习惯变化,其发病率和死亡率均逐渐升高。黄连素是一种异喹啉类生物碱,其广泛地存在于黄连等药用植物中。大量证据表明黄连素具有强大的抗炎、抗菌、抗肿瘤和抗糖尿病等药理作用。尤其,黄连素对于结直肠癌等多种肿瘤具有强烈的抑制作用。在此,本文从抑制结直肠癌细胞增殖和转移、诱导细胞凋亡、阻滞细胞周期、调节炎症反应、逆转化疗药物耐药性和调节肠道菌群等方面系统综述了黄连素抗结直肠癌作用,旨在阐明临床使用黄连素治疗结直肠癌的机制。
Colorectal cancer(CRC)is a common malignancy burdening people globally,with increasing morbidity and mortality nowadays,due to the alternation in the diet type and lifestyle in modern society.Berberine,a type of benzylisoquinoline alkaloid,is widely present in numerous medicinal plants,particularly including Coptidis Rhizoma.Mounting evidence reveals that berberine possesses an array of pharmacological effects,such as anti-inflammation,anti-bacterium,anti-cancer,anti-diabetes mellitus and so on.In particular,berberine exhibits substantial inhibition on various types of cancers including CRC.Hereby,we sought to systematically review the suppressive effect of berberine on CRC through the diminishment of the proliferation and metastasis,induction of apoptosis,arrest of cell cycle,regulation of inflammatory reaction,the reverse of chemotherapeutic resistance and restoration of gut microbiota in CRC,so as to shed light on the in-depth mechanisms underlying the treatment of CRC with berberine in the clinical setting.
作者
孙强
刘茂伦
任珊
杨寒
曾沙
陈莉
赵晖
明天琪
徐海波
SUN Qiang;LIU Mao-lun;REN Shan;YANG Han;ZENG Sha;CHEN Li;ZHAO Hui;MING Tian-qi;XU Hai-bo(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第2期343-352,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81573813,81173598)
成都中医药大学“杏林学者”基金项目(YXRC2019002,ZRYY1917)
成都中医药大学西南特色中药资源重点实验室开放研究基金资助项目(2020XSGG006)
四川省中医药管理局中医药科研专项课题(2021MS447)。
关键词
黄连素
结直肠癌
炎症
抗肿瘤
作用机制
berberine
colorectal cancer
inflammation
antitumor
mechanism
