摘要
目的探讨老年偏头痛患者血清8-羟基脱氧鸟苷酸(8-OHdG)、锰超氧化物歧化酶(MnSOD)水平与认知功能障碍的关系。方法选取本院2017年5月至2019年10月收治的256例偏头痛患者为研究对象,其中认知功能障碍患者126例为观察组,认知功能正常患者130例为对照组,采用酶联免疫吸附法检测血清8-OHdG水平,黄嘌呤氧化酶法检测血清MnSOD水平,Pearson法分析8-OHdG、MnSOD水平与蒙特利尔认知评估量表(MoCA)总分相关性;Logistic回归模型分析影响偏头痛患者发生认知功能障碍的因素。结果两组患者性别、年龄、体质量指数、受教育程度、病程、汉密尔顿抑郁量表-24项(HAMD-24)评分、有/无先兆偏头痛、脑白质疏松比例相比,差异均无统计学意义(P>0.05)。与对照组相比,观察组血清5-羟色胺(5-HT)与8-OHdG水平显著升高(t=12.455、48.271,P<0.05),观察组血清MnSOD水平、视空间与执行功能、注意力、语言能力、延迟回忆、MoCA总分显著降低(t=26.684、5.460、4.178、3.383、16.916、20.061,P<0.05);Pearson相关分析结果显示,观察组血清8-OHdG水平与MoCA总分呈负相关(r=-0.475,P<0.05),MnSOD水平与MoCA总分呈正相关(r=0.553,P<0.05);多因素Logistic回归分析结果表明,8-OHdG高水平、MnSOD低水平均是影响偏头痛患者发生认知功能障碍的独立危险因素[OR(95%CI)=2.239(1.410~3.556)、2.216(1.468~3.344),P<0.05]。结论老年偏头痛患者血清8-OHdG水平较高,MnSOD水平较低,可能为老年偏头痛患者发生认知功能障碍的诊治提供参考依据。
Objective To investigate the relationship between the levels of 8-hydroxydeoxyguanosine(8-OHdG),manganese superoxide dismutase(MnSOD)and cognitive impairment in elderly migraine patients.Methods A total of 256 migraine patients in our hospital from May 2017 to October 2019 were selected,of which 126 patients with cognitive dysfunction were used as the observation group,and 130 patients with normal cognitive function were used as the control group.The level of serum 8-OHdG was detected by enzyme linked immunosorbent assay,the level of serum MnSOD was detected by xanthine oxidase method.The correlation between 8-OHDG and MnSOD levels and the total score of Montreal Cognitive Assessment(MOCA)was analyzed by Pearson method.In addition,Logistic regression model was used to analyze the factors influencing cognitive impairment in migraine patients.Results There was no statistically significant difference between the two groups in gender,age,body mass index(BMI),education level,course of disease,Hamilton Depression Scale-24(HAMD-24)score,migraine the proportion of aura and leukoaraiosis(P>0.05).Compared with the control group,the levels of serum 5-hydroxytryptamine(5-HT)and 8-OHdG in the observation group were higher(t=12.455,48.271;P<0.05),and the level of MnSOD,the total scores of visual space and executive function,attention,language ability,delayed memory and MoCA were lower(t=26.684,5.460,4.178,3.383,16.916,20.061;P<0.05).Pearson correlation analysis showed that the serum 8-OHdG level was negatively correlated with the total score of MoCA(r=-0.475,P<0.05),and the MnSOD level was positively correlated with the total score of MoCA(r=0.553,P<0.05).In addition,multivariate Logistic regression analysis showed that high level of 8-OHdG and low level of MnSOD were independent risk factors for cognitive impairment in migraine patients[OR(95%CI)=2.239(1.410-3.556),2.216(1.468-3.344);P<0.05].Conclusion The level of serum 8-OHdG is increased in the elderly patients with migraine,and the level of MnSOD is declined,which may provide reference for the diagnosis and treatment of cognitive dysfunction in the elderly migraine patients.
作者
郭翃江
张茗
严之红
窦立冬
纪红
Guo Hongjiang;Zhang Ming;Yan Zhihong;Dou Lidong;Ji Hong(Department of Geriatrics,Aerospace Center Hospital,Beijing 100049,China)
出处
《心脑血管病防治》
2022年第1期47-50,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
基金
中国航天科工集团有限公司资助项目(2019-LCYL-012)。
