摘要
先天性巨结肠(Hirschsprung's disease,HSCR)是一种常见的先天性消化道发育畸形,以病变肠管神经节细胞缺乏为特征,发病率约1/5000,男女比例约4∶1。HSCR的治疗主要包括手术治疗和非手术治疗,目前通过手术切除无神经节细胞肠段及移行段仍为HSCR的主要治疗方式。近年来,国内外学者对HSCR非手术治疗进行了深入研究,非手术治疗在HSCR患儿手术前、手术后解决排便问题方面起到了重要作用。本文从扩肛和灌肠、中医药治疗、肉毒素注射治疗、生物反馈治疗以及干细胞治疗等方面对HSCR非手术治疗研究进展进行综述。
As a congenital bowel disorder,Hirschsprung's disease(HSCR)is characterized by the absence of intestinal ganglion cells with a prevalence of 1/5000 and a male-to-female ratio of 4:1.Its treatment options include surgery and non-surgical measures.The major treatment remains surgical resection by removing ganglion-free intestine and transitional segments.Domestic and foreign scholars actively exploring non-surgical option have concluded that it plays an important role in resolving defecation problems before and after operation.This review summarized non-surgical option of HSCR from the aspects of anal dilation and enema,traditional Chinese medicine,botulinum toxin injection,biofeedback and stem-cell therapies.
作者
王吉
李智
Wang Ji;Li Zhi(Department of Pediatric Surgery,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430030,China)
出处
《临床小儿外科杂志》
CAS
CSCD
2022年第2期186-190,共5页
Journal of Clinical Pediatric Surgery
基金
国家自然科学基金项目(81400579)。
