摘要
目的探究外周血中性粒细胞与淋巴细胞比值(NLR)联合血小板与淋巴细胞比值(PLR)在诊断动脉粥样硬化性脑梗死(ACI)与预测斑块稳定性的价值。方法选取陕西省人民医院神经内二科2020年1月~2021年1月住院治疗的ACI患者54例作为脑梗死组,另选取同期健康体检者65例作为对照组。均进行颈动脉超声检查、外周血NLR,PLR检测,比较两组外周血NLR和PLR水平。采用受试者工作(ROC)曲线探究NLR和PLR诊断ACI的价值,对比不同稳定性斑块患者外周血NLR和PLR水平,探究二者之间关系及与斑块稳定性的相关性。结果脑梗死组外周血NLR(3.16±0.17 vs 2.23±0.12)和PLR(133.45±5.02 vs 111.04±7.56)水平高于对照组,差异均有统计学意义(t=4.723,2.150,均P<0.05);外周血NLR,PLR联合诊断ACI优于二者单独诊断(AUC 0.779,95%CI:0.677~0.881);易损斑块患者外周血NLR和PLR水平>稳定斑块患者>无斑块患者(NLR 3.21±11.05 vs 1.88±0.61,1.27±0.23,PLR 131.98±45.91 vs 99.85±34.22,73.07±18.55),差异有统计学意义(F=33.38,12.30,均P<0.05);多元logistic回归分析提示NLR是易损斑块的独立危险因素(P<0.01),但PLR不是易损斑块的独立危险因素(P=0.491)。结论外周血NLR和PLR水平有助于ACI的诊断,且NLR是颈动脉易损斑块发生的独立危险因素。
Objective To explore the value of peripheral blood neutrophil lymphocyte ratio(NLR)combined with platelet lymphocyte ratio(PLR)in the diagnosis of atherosclerotic cerebral infarction CACI and prediction of plaque stability.Methods 54 patients with ACI hospitalzed in the Second Department of Neurology of Shaanxi Provincial Hospital from January 2020 to January 2021 were selected as the cerebral infarction group,and 65 healthy subjects in the same period were selected as the control group.Carotid ultrasound,peripheral blood NLR and PLR were performed to compare the levels of NLR and PLR in the two group.The receiver operating(ROC)curve was used to explore the value of NLR and PLR in the diagnosis of ACI.The levels of NLR and PLR in peripheral bolld of patients with different stable plaques were compared to explore the relationship between NLR and PLR and the stability of plaques.Result The levels of NLR and PLR in cerebral infarction group were higher than those in healthy control group(NLR 3.16±0.17 vs 2.23±0.12;PLR 133.45±5.02 vs 111.04±7.56),the differences were statistically significant(t=4.723,2.150,P<0.05).The value of NLR combined with PLR in the diagnosis of ACI was better than their individual diagnostic value(AUC 0.779,95%CI 0.677~0.881).The levels of NLR and PLR in patients with vulnerable plaque>patients with stable plaque>patients without plaque(NLR 3.21±1.05 vs 1.88±0.61,1.27±0.23;PLR 131.98±45.91 vs 99.85±34.22,73.07±18.55),and the difference was statistically significant(F=33.38,12.30,all P<0.05).Multivariate logistic regression analysis suggested that NLR was an independent risk factor for vulnerable plaque(P<0.01).But PLR was not an independent risk factor of vulnerable plaque(P=0.475).Conclusion The levels of NLR and PLR in peripheral blood are helpful for the diagnosis of ACI,and NLR is an independent risk factor for the occurrence of unstable carotid plaque.
作者
袁丹
郭晓敏
刘波
YUAN Dan;GUO Xiao-min;LIU Bo(Department of Neurology,Shaanxi Provincial People’s Hospital,Xi’an 710068,China;Department of Ultrasound,Shaanxi Provincial People’s Hospital,Xi’an 710068,China)
出处
《现代检验医学杂志》
CAS
2022年第1期199-202,共4页
Journal of Modern Laboratory Medicine
基金
陕西省重点研发项目(S2020-YF-YBSF-0260)。
