摘要
目的探讨血常规和凝血常规联合检测对重症新型冠状病毒肺炎(COVID-19)的诊断价值。方法选取2020年1月21日至3月1日在该院住院治疗的53例COVID-19患者为研究对象,其中轻型和普通型患者35例纳入非重症组,重型和危重型患者18例纳入重症组。比较非重症组和重症组血常规和凝血常规指标的差异,建立Fisher线性判别函数,验证其对重症COVID-19的评估效能。结果重症组白细胞计数(WBC)、中性粒细胞计数(NEU)、凝血酶原时间(PT)、纤维蛋白原(FIB)和D-二聚体(D-D)水平明显高于非重症组,淋巴细胞计数(LYM)和凝血酶时间(TT)水平明显低于非重症组,差异有统计学意义(P<0.05)。与非重症患者入院第1天比较,重症患者入院第1天、第7天的WBC和NEU均明显升高,入院第1天LYM明显下降,差异有统计学意义(P<0.05)。Fisher线性判别函数:非重症Y1=0.303×年龄-8.194×WBC+8.517×NEU+22.111×LYM+21.523×PT+8.063×FIB+8.971×TT+0.793×D-D-230.536;重症Y2=0.340×年龄-8.822×WBC+9.545×NEU+21.970×LYM+22.386×PT+9.567×FIB+8.804×TT+0.998×D-D-247.277,该判别函数判断COVID-19病情的符合率为83.02%。结论重症COVID-19患者往往伴随着更严重的炎症及凝血功能障碍,采用血常规和凝血常规指标建立判别函数有助于预测疾病的严重程度。
Objective To explore the diagnostic value of combined blood routine and coagulation routine detection for severe Coronavirus Disease 2019(COVID-19).Methods A total of 53 COVID-19 patients who were hospitalized in the hospital from January 21 to March 1,2020 were selected as the research objects.Among them, 35 patients with mild and common types were included in the non-severe group, and 18 patients with severe and critical types were included in the severe group.Compared the difference of blood routine and coagulation routine indexes between the non-severe group and the severe group, established a Fisher linear discriminant function, and verified its evaluate efficacy for severe COVID-19.Results The white blood cell count(WBC),neutrophil count(NEU),prothrombin time(PT),fibrinogen(FIB) and D-dimer(D-D) levels in the severe group were significantly higher than those in the non-severe group, the levels of lymphocytes count(LYM) and thrombin time(TT) were significantly lower than those in the non-severe group, and the differences were statistically significant(P<0.05).Compared with non-severe patients on the first day of admission, WBC and NEU of severe patients increased significantly on the first and seventh days of admission, and LYM decreased significantly on the first day of admission, the differences were statistically significant(P<0.05).Fisher linear discriminant function: non-severe Y1=0.303×age-8.194×WBC+8.517×NEU+22.111×LYM+21.523×PT+8.063×FIB+8.971×TT+0.793×D-D-230.536;severe Y2=0.340×age-8.822×WBC+9.545×NEU+21.970×LYM+22.386×PT+9.567×FIB+8.804×TT+0.998×D-D-247.277.This discriminant function had a coincidence rate of 83.02% in judging the condition of COVID-19.Conclusion Severe COVID-19 patients are often accompanied by more severe inflammation and coagulation dysfunction.Using blood routine and coagulation routine indexes to establish a discriminant function can help predict the severity of the disease.
作者
段金霞
闫彬
孙潺
夏盼盼
DUAN Jinxia;YAN Bin;SUN Chan;XIA Panpan(Department of Clinical Laboratory Medicine,Nanyang Central Hospital,Nanyang,Henan 473000,China;Department of Respiratory and Critical Care Medicine,Nanyang Central Hospital,Nanyang,Henan 473000,China;Department of Infectious Diseases,Nanyang Central Hospital,Nanyang,Henan 473000,China)
出处
《检验医学与临床》
CAS
2022年第2期168-171,共4页
Laboratory Medicine and Clinic
基金
河南省南阳市重点研发与推广专项科技攻关项目(KJGG093)
河南省重点研发与推广专项科技攻关项目(212102310805)。
关键词
血常规
凝血常规
新型冠状病毒肺炎
blood routine
coagulation routine
Coronavirus Disease 2019
