摘要
目的:观察清热祛湿利胆汤联合西药治疗病毒性肝炎的临床疗效。方法:选取98例肝胆湿热型病毒性肝炎患者,按随机数字表法分为对照组及观察组各49例。对照组给予甘草酸二铵肠溶胶囊及恩替卡韦分散片进行常规治疗,观察组在对照组基础上加用清热祛湿利胆汤进行治疗,2组均治疗3个月。观察2组临床疗效,比较2组治疗前后中医证候评分、肝功能[谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转移酶(γ-GT)、总胆红素(TBil)及直接胆红素(DBil)],观察治疗后2组不良反应发生率。结果:治疗后,2组胁肋疼痛、口苦口干、食欲不振、倦怠乏力中医证候评分均较治疗前降低,观察组上述4项评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组临床疗效总有效率为89.80%,高于对照组69.39%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组ALT、AST、γ-GT、TBil、DBil水平均较治疗前降低,观察组上述5项水平均低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为10.20%,对照组不良反应发生率为28.57%,2组比较,差异有统计学意义(P<0.05)。结论:采用清热祛湿利胆汤联合西药治疗肝胆湿热型病毒性肝炎,可改善肝功能,缓解临床症状,用药安全性较高。
Objective:To observe the clinical effect of Qingre Qushi Lidan tang combined with western medicine for viral hepatitis.Methods:A total of 98 cases of patients with viral hepatitis of liver-gallbladder dampness-heat type were selected and divided into the control group and the observation group according to the random number table method,with 49 cases in each group.The control group was given routine treatment with diammonium glycyrrhizinate enteric-coated capsules and entecavir dispersible tablets,and the observation group was additionally treated with Qingre Qushi Lidan tang based on the treatment of the control group.Both groups were treated for three months.Clinical effects in the two groups were observed.Before and after treatment,Chinese medicine syndrome scores and the liver function[alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyltransferase(γ-GT),total bilirubin(TBil)and direct bilirubin(DBil)]were compared between the two groups.After treatment,incidence of adverse reactions was observed in the two groups.Results:After treatment,Chinese medicine syndrome scores of pain in ribs,bitter taste in the mouth and dry mouth,poor appetite,and fatigue and lack of strength in the two groups were decreased when compared with those before treatment,and the above four scores in the observation group were lower than those in the control group,differences being significant(P<0.05).After treatment,the total effective rate of clinical effect was 89.80%in the observation group,higher than that of 69.39%in the control group,the difference being significant(P<0.05).After treatment,levels of ALT,AST,γ-GT,TBil,and DBil in the two groups were decreased when compared with those before treatment,and the above five levels in the observation group were lower than those in the control group,differences being significant(P<0.05).The incidence of adverse reactions was 10.20%in the observation group and 28.57%in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Qingre Qushi Lidan tang combined with western medicine for viral hepatitis of liver-gallbladder dampness-heat type can improve the liver function and relieve clinical symptoms with high medication safety.
作者
李晓华
郭亚南
郭德洪
LI Xiaohua;GUO Yanan;GUO Dehong
出处
《新中医》
CAS
2021年第23期117-120,共4页
New Chinese Medicine
关键词
病毒性肝炎
肝胆湿热型
清热祛湿利胆汤
肝功能
Viral hepatitis
Liver-gallbladder dampness-heat type
Qingre Qushi Lidan tang
Liver function
