摘要
复发性口腔溃疡(ROU)是口腔黏膜的一种常见病,常累及唇、舌、口角、软腭、颊部、口底等部位黏膜,具有周期性复发的特点。其病因复杂,确切发病机制尚不清楚,可能与免疫因素、维生素缺乏、内分泌因素、感染、遗传、机械性或化学性刺激等因素有关。近年来,免疫因素[细胞免疫(T淋巴细胞亚群)、体液免疫(免疫球蛋白、补体)以及细胞因子(白细胞介素、γ干扰素等)]常被认为是ROU发病的重要因素之一。ROU患者的多种免疫相关因素水平紊乱失衡且比较复杂,揭示ROU与免疫因素的关系可为进一步研究ROU的病因以及免疫因素在ROU发病机制中的作用提供理论依据。
Recurrent oral ulcer(ROU)is a common disease of oral mucosa,often involving the the mucosa of lips,tongue,angulus oris,soft palate,buccal,and oral etc.,with the characteristics of periodic recurrence.Its etiology is complex,and the exact pathogenesis is not clear,which may be related to immune factors,vitamin deficiency,endocrine factors,infection,heredity,mechanical or chemical stimulation and other factors.In recent years,immune factors[cellular immunity(T lymphocyte subsets),humoral immunity(immunoglobulin,complement)and cytokines(interleukin,γ-interferon,etc.)]are often considered as one of the important factors of ROU.The levels of multiple immune related factors in patients with ROU are disordered,unbalanced and complex,revealing the relationship between ROU and immune factors,which can provide a theoretical basis for further studying the etiology of ROU and the role of immune factors in the pathogenesis.
作者
许郑林
王蕾
靳泳秀
侯建章
XU Zhenglin;WANG Lei;JIN Yongxiu;HOU Jianzhang(Department of Pathogenic Biology and Immunology,Cangzhou Medical College,Cangzhou 061001,China;Hebei Medical University,Shijiazhuang 050017,China;Department of Hepatobiliary and Pancreatic Surgery,Cangzhou People′s Hospital,Cangzhou 061001,China)
出处
《医学综述》
CAS
2021年第24期4893-4897,共5页
Medical Recapitulate
关键词
复发性口腔溃疡
免疫相关因素
紊乱失衡
Recurrent oral ulcer
Immune-related factors
Disorder and imbalance
