摘要
目的探讨多西他赛联合奥沙利铂同步放化疗治疗非小细胞肺癌(NSCLC)的临床应用效果。方法将该院2016年6月—2018年6月收治的70例NSCLC患者纳入研究,按照患者的治疗方案将患者分成两组,其中对照组(n=35)采用单纯常规放疗治疗,观察组(n=35)在对照组基础上增加同步化疗,予以患者多西他赛75 mg/m^(2)和奥沙利铂130 mg/m^(2)静脉化疗。对比两组患者治疗方案效果、生存状态、不良反应发生情况。结果观察组治疗总有效率为51.43%,明显高于对照组的25.71%,差异有统计学意义(χ^(2)=4.884,P=0.027)。观察组患者中位生存时间为(14.36±3.75)个月,长于对照组患者的(8.86±2.48)个月,差异有统计学意义(t=7.237,P<0.001)。观察组患者粒细胞减少、骨髓抑制发生率为28.57%、31.43%,高于对照组的8.57%、17.14%,差异有统计学意义(χ^(2)=4.629,4.158,P<0.05)。结论多西他赛联合奥沙利铂同步放化疗治疗NSCLC,其临床应用效果较好,能有效控制肿瘤的发展,一定程度上延长患者的生存时间,但依然有较高的不良反应。
Objective To investigate the clinical application effect of docetaxel combined with oxaliplatin in the treatment of non-small cell lung cancer(NSCLC).Methods The 70 NSCLC patients admitted to the hospital from June 2016 to June 2018 were included in the study,and the patients were divided into two groups according to the patient's treatment plan.The control group(n=35)was treated with conventional radiotherapy alone.The observation group(n=35)added concurrent chemotherapy to the control group,and received intravenous chemotherapy with docetaxel 75 mg/m^(2) and oxaliplatin 130 mg/m^(2).Compared the effects of the treatment plan,survival status,and occurrence of adverse reactions between the two groups of patients.Results The total effective rate of treatment in the observation group was 51.43%,which was significantly higher than 25.71%in the control group,the difference was statistically significant(χ^(2)=4.884,P=0.027).The median survival time of patients in the observation group was(14.36±3.75)months,which was longer than(8.86±2.48)months of patients in the control group,the difference was statistically significant(t=7.237,P<0.001).The incidence of granulocytopenia and bone marrow suppression in the observation group was 28.57% and 31.43%,which were higher than those in the control group,which were 8.57% and 17.14%,the difference was statistically significant(χ^(2)=4.629,4.158,P<0.05).Conclusion Docetaxel combined with oxaliplatin combined with concurrent radiotherapy and chemotherapy for NSCLC has a good clinical application effect,which can effectively control the development of tumors and prolong the survival time of patients to a certain extent,but still has high adverse reactions.
作者
尹星
鲍淑文
曹莹
郑琳巾
YIN Xing;BAO Shuwen;CAO Ying;ZHENG Linjin(Department of Radiation Oncology,Suzhou Kowloon Hospital,Shanghai Jiaotong University School of Medicine,Suzhou,Jiangsu Province,215028 China)
出处
《系统医学》
2021年第21期170-173,共4页
Systems Medicine
基金
扬州市科学技术局2018年市级计划-社会发展(YZ2018082)。
关键词
非小细胞肺癌
奥沙利铂
多西他赛
同步放化疗
应用效果
Non-small cell lung cancer
Oxaliplatin
Docetaxel
Concurrent chemoradiation
Application effect
