摘要
目的比较经口内镜下贲门缩窄术(PECC)与双倍剂量艾司奥美拉唑治疗难治性胃食管反流病(rGERD)的临床疗效。方法选取保定市第一中心医院2019年1月至2020年5月的rGERD患者64例进行前瞻性随机对照研究。按照随机对照原则将符合纳入标准患者分为PECC组及艾司奥美拉唑组,每组各32例。前者接受PECC治疗,后者口服艾司奥美拉唑及枸橼酸莫沙比利,对比两组患者治疗后3、6个月反流症状、生活质量评分及满意度。结果PECC组患者治疗后3个月及6个月反流性疾病问卷(RDQ)、反流症状指数评分量表(RSI)、胃食管反流病健康相关生活质量评分(GERD-HRQL),评分均明显低于艾司奥美拉唑组(P<0.01)。治疗后6个月PECC组满意度为87.5%(28/32)、艾司奥美拉唑组满意度为40.63%(13/32)。两组患者满意度有统计学差异(P<0.05),且PECC组患者无明显严重并发症。结论短期疗效来说PECC比两倍剂量艾司奥美拉唑在改善rGERD患者反流症状及提高生活质量方面更有优势,可缓解rGERD咽喉反流症状,显著改善rGERD反酸、烧心等食管反流症状,明显提高生活质量,可以作为rGERD治疗选择方案。
Objective To compare the clinical efficacy of peroral endoscopic cardial constriction(PECC)and double-dose esomeprazole on the treatment of refractory gastroesophageal reflux disease(rGERD).Methods A prospective randomized controlled study was conducted on the data of 64 patients with rGERD at Baoding No.1 Central Hospital from January 2019 to May 2020.According to the principle of randomized control trial,patients were divided into PECC group and esomeprazole group,with 32 cases in each group.The former under went PECC and the latter taken oral esomeprazole and mosapride citrate.The reflux symptoms,quality of life scores and satisfaction between the two groups were compared after 3 and 6 months.Results After 3 and 6 months follow-up reflux disease questionnaire(RDQ),reflux symptom index(RSI),health related quality of life scale gastroesophageal reflux disease(GERD-HRQL)scores in the PECC group were significantly lower than those in the esomeprazole group(P<0.01).After 6 months follow-up,the satisfaction rate of PECC group and esomeprazole group was 87.5%(28/32)and 40.63%(13/32),respectively.There was significant difference in satisfaction between the two groups(P<0.05),and no obvious serious complications in the PECC group.Conclusion In terms of short-term efficacy,PECC is more advantageous than double-dose esomeprazole in improving reflux symptoms and enhancing quality of life in patients with rGERD.It can alleviate the symptoms of rGERD throat reflux,and significantly reduce rGERD acid reflux、heartburn and other esophageal reflux symptoms.It can distinctly improve the quality of life and can be used as a treatment option for rGERD.
作者
曹会霞
熊英
韩静
张金卓
杨义超
王亚玲
杨崇阳
Cao Huixia;Xiong Ying;Han Jing;Zhang Jinzhuo;Yang Yichao;Wang Yaling;Yang Chongyang(Chengde Medical University,Chengde 067000, China;Department of Digestive,Baoding No.1 Central Hospital,Baoding 071000, China;Endoscopy Center,Baoding No.1 Central Hospital,Baoding 071000,China;Department of Otolaryngology, Baoding No.1 Central Hospital,Baoding 071000,China)
出处
《中华胃肠内镜电子杂志》
2021年第4期171-175,共5页
Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)
基金
河北省保定市科技计划项目(1951ZF067)。
关键词
经口内镜下贲门缩窄术
艾司奥美拉唑
难治性胃食管反流病
反流症状
满意度
Peroral endoscopic cardial constriction
Esomeprazole
Refractory gastroesophageal reflux disease
Relieve symptoms
Satisfaction
