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血清乳酸脱氢酶、铁蛋白和血小板生成素在急性白血病与骨髓异常增生综合征鉴别诊断中的应用

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摘要 目的:研究血清乳酸脱氢酶(Lactate dehydro-genase,LDH)、铁蛋白(Serum ferritin,SF)和血小板生成素(Thrombopoietin,TPO)对急性白血病(Acute leukemia,AL)和骨髓异常增生综合征(Myelodysplastic syndrome,MDS)鉴别诊断价值。方法:选取2016年9月至2018年9月我院收治的AL患者71例(AL组)和MDS患者52例(MDS组),测定血清LDH、SF和TPO水平,并采用ROC曲线分析LDH、SF、TPO及三者联合检测对两种疾病的鉴别诊断价值。结果:AL组血清LDH及TPO水平明显高于MDS组,血清SF水平明显低于MDS组(P<0.05);三者与AL均密切相关(P<0.05),对AL和MDS鉴别诊断AUC分别为0.684、0.814和0.922,且三者联合诊断AUC达0.963,较单独应用明显升高(P<0.05)。结论:血清LDH、SF和TPO在AL和MDS患者中表达水平存在显著差异,对临床鉴别诊断具有良好参考意义。
作者 黄小华
出处 《四川生理科学杂志》 2021年第9期1546-1548,共3页 Sichuan Journal of Physiological Sciences
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