摘要
近年来研究发现B族维生素参与了很多重要的生物反应过程,除了在人体代谢中发挥传统的作用外,还可以通过抑制细胞增殖、促进细胞自噬、诱导细胞凋亡等作用机制达到抗结肠癌的作用。临床研究结果提示B族维生素在辅助治疗结肠癌方面起到一定的作用,未来仍需进一步开展B族维生素药理机制研究,并将其逐步应用到结肠癌的治疗中,有望成为更新、更有效的抗结肠癌药物。
In recent years,studies have found that B vitamins participate in many important biological reaction processes.In addition to playing a traditional role in human metabolism,they can also play an anti colon cancer role by effect mechanism such as inhibiting cell proliferation,promoting autophagy,and inducing apoptosis.The clinical research results suggest that B vitamins play a certain role in the adjuvant treatment of colon cancer.In the future,more research on pharmacological mechanism of B vitamins should be conducted and gradually applied in the treatment of colon cancer.And B vitamins are expected to become one kind of new and more effective anti-colon cancer drugs.
作者
高宇菲
潘开彪
王子娴
李玲丽
王海鹏
宋家乐
GAO Yu-fei;PAN Kai-biao;WANG Zi-xian;LI Ling-li;WANG Hai-peng;SONG Jia-le(School of Public Health,Guilin Medical University,Guilin GUANGXI 541199,China;School of General Medical,Guilin Medical University,Guilin GUANGXI 541199,China;Department of Clinical Nutrition,the Second Affiliated Hospital,Guilin Medical University,Guilin GUANGXI 541199,China;Department of Gastrointestinal Surgery,the Second Affiliated Hospital,Guilin Medical University,Guilin GUANGXI 541199,China;Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care,Guilin GUANGXI 541199,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2021年第11期737-741,共5页
Chinese Journal of New Drugs and Clinical Remedies
基金
国家自然科学基金(81560530,81760589,81960590)
人社部“高层次留学人才回国资助计划”(人社厅函[2019]160号)
广西自然科学基金(2016GXNSFCA380026
2020GXNSFAA159160)
广西高等学校千名中青年骨干教师培育计划(桂教人[2018]18号)
教育部区域性高发肿瘤早期防治研究重点实验室开放课题(GKE2018-KF03)
桂林医学院引进人才科研启动基金(04010150001)。
关键词
结肠肿瘤
B族维生素
抗肿瘤药
肿瘤辅助疗法
colonic neoplasms
B vitamins
antineoplastic agents
neoadjuvant therapy
