摘要
据2020年世界癌症数据报告显示,前列腺癌的患病率居男性恶性肿瘤的第2位,死亡率的第5位。在我国由于不良的生活和饮食习惯的影响,前列腺癌的患病率仍在不断上升,但由于晚期前列腺癌可通过多种机制对雄激素去势治疗相关药物产生适应和耐受,晚期前列腺癌的治疗,往往难以取得有效的治疗效果。鱼腥草是三白草科蕺菜属植物,是国家卫生健康委员会正式确定为药食两用的品种之一。迄今为止的研究表明鱼腥草可通过多靶点、多环节、多途径对前列腺癌产生抑制增殖、诱导凋亡和细胞周期停滞、抑制迁移和侵袭等抗肿瘤生物活性作用,这些抗肿瘤活性可在乳腺癌、白血病、胃癌、结直肠癌等多种肿瘤细胞中观察到。这些抗肿瘤活性主要体现在抑制细胞周期蛋白(Cyclin)和细胞周期蛋白激酶的表达,调节凋亡相关蛋白的表达并激活凋亡相关通路,减少基质金属蛋白的分泌,抑制信号转导与转录激活因子3(STAT3)/锌指蛋白(Snail)/转录因子Twist(Twist)通路,拮抗生长因子受体、雄激素、炎症及氧化应激在前列腺癌发生和发展过程中的促进作用。另外研究显示鱼腥草也可以通过抑制蛋白激酶B(Akt)/雷帕霉素靶蛋白(mTOR)和丝裂原活化蛋白激酶(MAPK)信号通路,改善糖尿病,调节降血糖的相关通路并增强机体免疫力等方式实现对前列腺癌的发生和进展产生抑制。综上所述,鱼腥草可作为抗前列腺癌的潜在药物。
According to the 2020 world cancer data report,the prevalence of prostate cancer ranks second in male malignant tumors and the mortality fifth.In China,due to the poor living and eating habits,the prevalence of prostate cancer is still rising,and advanced prostate cancer can adapt to and tolerate androgen castration related drugs through a variety of mechanisms,which often indicates poor therapeutic outcomes in the late stage.Houttuyniae Herba,a medicinal plant of family Saururaceae,has been officially identified both as food and medicine by the National Health Commission.The existing studies have shown that Houttuyniae Herba inhibits the proliferation,migration,and invasion of prostate cancer and induces its apoptosis and cell cycle arrest via multiple targets,links,and pathways.These anti-tumor activities can also be observed in breast cancer,leukemia,gastric cancer,colorectal cancer,and other tumor cells.Such activities are mainly related to the inhibited expression of cyclin and cyclin-dependent kinase,regulation of apoptosis-related proteins,activation of apoptosis-related pathways,reduced secretion of matrix metalloproteinase,inhibition of activator of transcription 3(STAT3)/Zinc finger protein(Snail)/transcription factor twist signaling pathway,and antagonization of growth factor receptor,androgen,inflammation,and oxidative stress in promoting the occurrence and development of prostate cancer.In addition,Houttuyniae Herba is able to alleviate diabetes,regulate blood glucose-lowering pathways,and boost immunity by inhibiting the protein kinase B(Akt)/mammalian target of rapamycin(mTOR)and mitogen-activated protein kinase(MAPK)signaling pathways,thus suppressing the occurrence and progression of prostatic cancer.In conclusion,Houttuyniae Herba can be used as a potential drug against prostate cancer.
作者
李威
张峻豪
许盛涵
车邦威
黄涛
唐开发
LI Wei;ZHANG Jun-hao;XU Sheng-han;CHE Bang-wei;HUANG Tao;TANG Kai-fa(Guizhou Medical University,Guiyang 550004,China;Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Institute of Medical Sciences,Guizhou Medical University,Guiyang 550004,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第24期243-250,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81660263)。
关键词
鱼腥草
前列腺癌
细胞凋亡
炎症
糖尿病
免疫力
Houttuyniae Herba
prostate cancer
apoptosis
inflammation
diabetes
immunity
