摘要
肝脏缺血-再灌注损伤(HIRI)是一种由肝脏血供停止后所致的原发性损伤和循环恢复后导致的继发性损伤累积的过程。HIRI可造成肝脏切除或者肝移植患者肝脏功能的受损,导致手术失败甚至患者死亡,是受到广泛关注和亟待解决的问题。目前针对HIRI后肝脏组织损伤和功能障碍的治疗未取得理想的效果,基于其病理生理机制的干预和临床实践亦未取得长足的进步。本文对HIRI的防治策略和临床应用现状及其相关基础研究进行阐述。
Hepatic ischemia-reperfusion injury(HIRI)is a process of a primary injury caused by the cessation of blood supply of the liver and the accumulated of secondary injury caused by the reconstruction of circulation.HIRI can cause liver function damage in patients with partial liver resection or liver transplantation,leading to surgical failure and even death of patients,which is a problem that has attracted wide attention and needs to be solved urgently at present.Currently,no significant progress has been made in the treatment of HIRI,so as in the intervention and clinical practice based on its pathophysiological mechanism.This paper focuses on the prevention and treatment strategies,clinical application status,and related basic research of HIRI.
作者
谭思由
陈文雁
苏颖颖
孔高茵
刘永平
魏来
TAN Siyou;CHEN Wenyan;SU Yingying;KONG Gaoyin;LIU Yongping;WEI Lai(Department of Anesthesiology,Hunan Provincial People’s Hospital/the First Affiliated Hospital of Hunan Normal University,Changsha 410005,China)
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2021年第10期1106-1110,共5页
Journal of Clinical Anesthesiology
基金
湖南省科学技术厅项目(2018SK7001)
湖南中医药管理局项目(202071)。
关键词
肝脏缺血-再灌注损伤
防治策略
炎症
氧化应激
Hepatic ischemia-reperfusion injury
Prevention and treatment strategy
Inflammation
Oxidative stress
