摘要
Although iron oxide(Fe_(3)O_(4)) nanoparticles have broad application prospects as magnetic resonance imaging(MRI) contrast agent, their biocompatibility and biotoxicity still need to be improved. In this study, we prepared Fe_(3)O_(4)@Angelica sinensis polysaccharide nanoparticles(Fe_(3)O_(4)@ASP NPs) with a 9 nm Fe_(3)O_(4) core and ASP as the coating material. The Fe_(3)O_(4)@ASP NPs are superparamagnetic, can be taken up by liver and spleen macrophages in the circulatory system in vivo, and are a good-biocompatibility and low-toxicity transverse relaxation time(T_(2)) and T_(2)-star(T_(2)^(*)) magnetic resonance imaging(MRI) contrast agent for the liver. The cytotoxicity assessment using HeLa cells and the pathological tests in mice validate that Fe_(3)O_(4)@ASP NPs have low toxicity and good biocompatibility in vivo, which can be attributed to the ASP as a natural polysaccharide with good biocompatibility and its function of protecting the liver. Fe_(3)O_(4)@ASP NPs are a potential new MRI contrast agent with high signal intensity in vivo.
出处
《Rare Metals》
SCIE
EI
CAS
CSCD
2021年第9期2486-2493,共8页
稀有金属（英文版）
基金
financially supported by the National Key Research and Development Program of China(No.2019YFB2005801)
the National Natural Science Foundation of China(Nos.51671019,51731003,51971024,51927802 and 51971023)
Beijing Natural Science Foundation Key Program(No.Z190007)
Fundamental Research Funds for the Central Universities(No.FRF-MP-19-004)。
