摘要
老年认知障碍的患者常伴随着昼夜节律紊乱。研究表明,时钟基因参与认知过程,且其表达异常与多种年龄相关认知障碍疾病的发生、发展密切相关。文章在简要阐述时钟基因的基础上,就时钟基因在几种与年龄相关的认知障碍疾病中的研究进展进行综述,为及早预防、诊断和治疗老年认知障碍疾病提供新的靶点。
Age patients with cognitive impairment are often accompanied by circadian rhythm disturbance.Studies have shown that clock genes are involved in cognitive processes,and their abnormal expression is closely related to the occurrence and development of a variety of age related cognitive disorders.Based on the brief introduction of clock gene,this review summarizes the research advances of clock gene in several age related cognitive disorders,so as to provide a new target for early prevention,diagnosis and treatment of cognitive disorders in elder patients.
作者
杨宇荣
邱颐
王晓冬
Yang Yurong;Qiu Yi;Wang Xiaodong(Graduate School of Inner Mongolia Medical University,Hohhot 010110,China;Department of Anesthesiology,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China)
出处
《国际麻醉学与复苏杂志》
CAS
2021年第10期1098-1102,共5页
International Journal of Anesthesiology and Resuscitation
基金
内蒙古自治区自然科学基金(2018LH08029)。
关键词
时钟基因
昼夜节律
年龄
认知障碍
Clock gene
Circadian rhythm
Age
Cognitive impairment
