摘要
目的基于真实世界研究探析纯中药治疗2型糖尿病(T2DM)的临床疗效及对胰岛功能的影响。方法收集自2018年8月—2020年8月间来自5家医疗机构的T2DM患者252例,采用纯中药"序贯三法"治疗,12周为1疗程,观察治疗前后空腹血糖(FBG)、餐后2 h血糖(2hPG)、空腹及餐后1 h、2 h、3 h胰岛素水平,空腹及餐后1 h、2 h、3 h胰高血糖素水平,胰岛β细胞功能(HOMA-βF)水平改善情况。结果本研究受试者252例,治疗后空腹血糖(FBG)、餐后2 h血糖(2hPG)均显著下降,差异具有统计学意义(P<0.01);空腹及餐后1 h、2 h胰岛素水平较治疗前明显升高,差异具有统计学意义(P<0.01)。餐后3 h胰岛素水平无明显变化,差异无统计学意义(P>0.05);空腹及餐后1 h、2 h、3 h胰高血糖素水平较治疗前明显下降,差异具有统计学意义(P<0.01);胰岛β细胞功能(HOMA-βF)较治疗前明显上升,差异具有统计学意义(P<0.01)。结论纯中药"序贯三法"治疗T2DM临床疗效确切,能有效降低血糖、改善胰岛素分泌,降低胰岛素抵抗,降低胰高血糖素,改善患者胰岛功能,疗效确切,值得临床推广。
Objective To observe the clinical efficacy of pure Chinese medicine in the treatment of type 2 diabetes mellitus and its effect on islet function based on the real world research.Methods A total of 252 patients with type 2 diabetes who met the diagnostic criteria were collected from 5 Chinese hospitals from August 2018 to August 2020. They were treated with pure Chinese medicine "sequential three methods" for a course of 12 weeks.Fasting blood glucose(FBG), 2 h postprandial blood glucose(2 hPG), fasting and 1 h, 2 h, 3 h postprandial insulin levels, fasting and 1 h, 2 h, 3 h postprandial glucagon levels, and islet β-cell function(HOMA-βF) levels were observed before and after treatment.Results A total of 252 subjects were included in this study. After treatment, both FBG and 2 hPG were decreased significantly(P<0.01).The fasting and 1 h and 2 h insulin levels were significantly higher than those before treatment(P<0.01).There was no significant difference in insulin level at 3 h after meals(P>0.05).The levels of glucagon in fasting and 1 h, 2 h and 3 h after meals were significantly lower than those before treatment(P<0.01).The function of HOMA-βF was significantly increased compared with that before treatment(P<0.01).Conclusion The pure traditional Chinese medicine "sequential three methods" has a definite clinical effect on the treatment of type 2 diabetes mellitus, which can effectively reduce blood glucose, improve insulin secretion, reduce insulin resistance, and improve the function of islet β-cell in patients. The curative effect is definite and it is worthy of further clinical promotion.
作者
庞国明
张芳
李鹏辉
姚沛雨
马宇鹏
朱璞
武楠
平佳宜
鲍玉晓
王志强
付永祥
李方旭
王银姗
娄静
翟纪功
高言歌
陈丹丹
孔丽丽
曹秋平
叶乃菁
南凤尾
陈杰
郑文静
王凯锋
PANG Guoming;ZHANG Fang;LI Penghui;YAO Peiyu;MA Yupeng;ZHU Pu;WU Nan;PING Jiayi;BAO Yuxiao;WANG Zhiqiang;FU Yongxiang;LI Fangxu;WANG Yinshan;LOU Jing;ZHAI Jigong;GAO Yange;CHEN Dandan;KONG Lili;CAO Qiuping;YE Naijing;NAN Fengwei;CHEN Jie;ZHENG Wenjing;WANG Kaifeng(Kaifeng Hospital of Traditional Chinese Medicine,Kengfeng 475000,Henan,China;Shenzhen Hospital of Beijing University of Traditional Chinese Medicine,Shenzhen 518000,Guangdong,China;SichuanSecond Hospital of Traditional Chinese Medicine,Chengdu 610000,Sichuan,China;Yangzhou Hospital of Traditional Chinese Medicine,Yangzhou 225000,Jiangsu,China;Zhenjiang Hospital of Traditional Chinese Medicine,Zhenjiang 212000,Jiangsu,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第10期253-258,共6页
Chinese Archives of Traditional Chinese Medicine
基金
河南省中医药科学研究专项课题(2018ZY3024)。
关键词
真实世界研究
2型糖尿病
纯中药治疗
序贯三法
胰岛功能
real world research
type 2 diabetes
pure Chinese medicine treatment
sequential three methods
islet function
