摘要
目的:探讨奥曲肽联合奥美拉唑治疗肝硬化上消化道出血的疗效。方法:选取60例肝硬化上消化道出血患者为研究对象,随机分为对照组和研究组各30例。两组均给予垂体后叶素治疗,对照组联合奥美拉唑治疗,研究组在对照组的基础上联合奥曲肽治疗。比较两组患者的疗效、临床参数变化。结果:研究组的治疗有效率高于对照组、48 h后再出血率低于对照组、复发率低于对照组;研究组的止血时间更短,血清胰高血糖素、血清NO浓度优于对照组(P<0.05)。结论:奥曲肽联合奥美拉唑治疗肝硬化上消化道出血,能够提高疗效,改善患者血流动力学参数,降低疾病复发率。
Objective:To explore the effect of octreotide combined with omeprazole in the treatment of liver cirrhosis with acute variceal rupture bleeding.Methods:Sixty patients with liver cirrhosis and upper gastrointestinal hemorrhage were selected as the research subjects and randomly divided into a control group and a study group with 30 cases each.Both groups were treated with pituitrin,besides,the control group was given omeprazole and the study group was given octreotide combined with omeprazole.The treatment efficiency and clinical parameter changes were compared between the two groups.Results:The effective rate of treatment of patients was higher,the rebleeding rate 48 hours after treatment and the recurrence rate were lower,the hemostasis time was shorter and the serum levels of glucagon and nitric oxide were better in the study group than the control group(P<0.05).Conclusion:The combination of octreotide and omeprazole for the treatment of the upper gastrointestinal bleeding with liver cirrhosis can significantly improve the therapeutic effect and the hemodynamics of patients and reduce the recurrence rate of the disease.
作者
乐虎安
付丽园
周斌
LE Hu’an;FU Liyuan;ZHOU Bin(Department of Gastroenterology,the First People’s Hospital of Fuzhou,Fuzhou 344000,China)
出处
《上海医药》
CAS
2021年第21期46-48,共3页
Shanghai Medical & Pharmaceutical Journal
关键词
奥曲肽
奥美拉唑
肝硬化
上消化道出血
octreotide
omeprazole
liver cirrhosis
upper gastrointestinal bleeding
