摘要
病毒聚合酶是一类十分重要的合成病毒自身遗传物质的蛋白质,因其相对保守而成为抗病毒药物研发的重要靶点。不同病毒聚合酶的结构和功能有着许多相似之处,因此针对某一种病毒聚合酶设计的抑制剂往往对其他病毒也有较好的抑制作用。本文作者精选了近年以聚合酶为靶点的抗病毒药物的经典案例,介绍了不同病毒聚合酶的结构和功能,并从药物化学的角度综述了多种病毒聚合酶抑制剂的研究进展。
Virus polymerase is a kind of very important proteins that synthesizes its own genetic material.Polymerases are relatively conservative,so they are important targets for the development of antiviral drugs.There are many similarities in the structure and function of different virus polymerases,so the inhibitors designed for one kind of virus polymerase often have good inhibitory effect on other viruses.In this paper,we selected the representative cases in recent years,introduced the structure and function of different virus polymerases,and reviewed the research progress of virus polymerase inhibitors from the perspective of medicinal chemistry.
作者
张莹
侯凌欣
鞠翰
刘新泳
展鹏
ZHANG Ying;HOU Ling-xin;JU Han;LIU Xin-yong;ZHAN Peng(Department of Medicinal Chemistry,Key laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Ji'nan 250012,China)
出处
《中国药物化学杂志》
CAS
CSCD
2021年第9期657-679,共23页
Chinese Journal of Medicinal Chemistry
基金
国家自然科学基金项目(81773574)
山东省杰出青年基金项目(ZR2020JQ31)
山东省重大科技创新工程项目(2019JZZY021011)。
