摘要
细菌疫苗仍然是公共卫生防疫不可或缺的重要科学手段。近年来,医学、生物学、材料学等学科前沿领域的快速发展,不断推动已上市细菌疫苗品种升级优化,以满足人们日益增长的健康需求。与此同时,原创细菌疫苗在异常艰难的探索中取得诸多重大突破,以应对日趋严峻的超级耐药细菌。细菌比病毒颗粒大数10倍,且以独立生命体生存,基因组庞大,可形成芽孢、L形变异体、鞭毛、荚膜等特殊结构,其复杂的构造及高度的进化及繁衍能力,给细菌疫苗研制带来巨大挑战。前沿科学的不断突破与交叉融合,为解决上述挑战带来新的希望。本文对近年来创新细菌疫苗研发取得的突破和面临的挑战作一简要综述。
Bacterial vaccines remain an indispensable and essential scientific tool for public health.In recent years,rapid advances in medicine,biology,materials science and other subjects have driven the continuous upgrading and optimization of marketed bacterial vaccines to meet the increasing health needs of the population.At the same time,original vaccines have achieved many breakthroughs to deal with the growing number of super drug-resistant bacteria.Bacteria are tens of times bigger than viral particles.They survive as independent living organisms with large genomes,forming unique structures such as spores,L-phase variants,flagella and capsules.Their complex system and high ability to evolve and reproduce lead to number of challenges to bacterial vaccine development.The continuous breakthroughs and cross-fertilization of frontier science have brought new hope to solve the above challenges.In this review the advances and challenges in research on innovative bacterial vaccine in recent years are discussed.
作者
顾江
曾浩
邹全明
GU Jiang;ZENG Hao;ZOU Quan-ming(National Engineering Research Center of Immunological Products,Army Medical University,Chongqing 400038,China)
出处
《中国生物制品学杂志》
CAS
CSCD
北大核心
2021年第9期1017-1022,共6页
Chinese Journal of Biologicals
关键词
创新细菌疫苗
进展
挑战
Innovative bacterial vaccine
Progress
Challenge
