摘要
细胞凋亡在多细胞生物中广泛存在,对于细胞正常生命活动是不可缺少的生理过程。Bcl-2家族分子是参与调控细胞凋亡信号途径的一类分子,通过促凋亡和抑凋亡分子相互作用来控制细胞的凋亡和存活,是细胞凋亡研究中最深入广泛的一类分子。在哺乳动物,Bcl-2家族分子的研究有利于研发临床治疗肿瘤的药物,或监测肿瘤发生发展的程度。而在节肢动物,相关研究有利于害虫的生物防控。论文就Bcl-2家族分子功能及其在不同物种的作用机制进行综述。
Apoptosis is an essential physiological process which widely occurs in multicellular organisms.Bcl-2 family,the best characterized molecules are mainly involved in regulating the signaling pathway of cell apoptosis,via the interaction between anti-apoptotic and pro-apoptotic molecules.Currently,the regulatory mechanism of Bcl-2 molecules during apoptosis has been attracting a wide research attention.Recent studies that are conducted in mammals had revealed that Bcl-2 family molecules are beneficial to find new drugs for cancer and to monitor the developmental stages of tumor.Moreover,arthropod based study findings indicated that Bcl-2 family molecules are used to biologically control pests.Therefore,the review article has compiled recent research findings regarding the role of Bcl-2 family molecules during apoptosis,in different species.
作者
胡善明
王亚楠
许正茂
周金林
HU Shang-ming;WANG Ya-nan;XU Zheng-mao;ZHOU Jin-lin(Key Laboratory of Animal Parasitology of Ministry of Agriculture,Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Shanghai,200241,China)
出处
《动物医学进展》
北大核心
2021年第10期85-89,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(31572512)。
